Publications by authors named "Ken-ichi Koyama"
Yakugaku Zasshi
December 2009
Article Synopsis
- Researchers created microparticles that encapsulate a substance called lactoferrin (LF) using alginate and calcium, then coated them with chitosan for better durability in the gastrointestinal tract.
- The final chitosan-coated microparticles were uniform in size and shape but showed a decrease in lactoferrin content and recovery as chitosan concentration increased.
- Microparticles coated with lower concentrations of chitosan released lactoferrin gradually in lab tests and remained stable in acidic and neutral conditions, indicating they could effectively deliver lactoferrin in the intestines.
J Infect Chemother
April 2009
Article Synopsis
- A 44-year-old woman developed disseminated Mycobacterium avium complex (MAC) infections with multiple bone lesions after being healthy for 6 months.
- Tests showed that her immune cells produced little to no interferon-gamma (IFN-gamma) when exposed to her plasma, indicating a problem with her immune response.
- The suspected issue was anti-IFN-gamma autoantibodies in her plasma, which did not significantly decrease after treatment with intravenous immunoglobulin (IVIG), marking this as a rare case in Japan.
Article Synopsis
- - * Researchers created nanoparticles called CPT-NP using poly(DL-lactic acid) and a specific copolymer, loading them with the cancer drug camptothecin (CPT) to study their behavior in a saline solution and in tumor-bearing mice.
- - * The nanoparticles maintained a consistent size and released about 20% of the drug quickly, followed by a much slower release rate after that initial burst.
- - * Compared to regular CPT solution, CPT-NP showed improved drug accumulation in tissues and better targeting of tumors, which enhances the effectiveness of the treatment.
