Sex and Age Stratified Voice Data in Japanese Vocally Healthy Individuals: Vocal Capacity.

Objective: There is no normative voice dataset regarding the vocal capacity of Japanese speakers in the English literature. We collected age- and sex-stratified data on the vocal capacity of vocally healthy Japanese speakers.

Methods: In total, 111 vocally healthy Japanese speakers (42 men and 69 women) were divided into the young (13 men and 30 women), middle-aged (18 men and 27 women), and elderly (11 men and 12 women) groups.

Gender- and Age- Stratified Normative Voice Data in Japanese-Speaking Subjects: Analysis of Sustained Habitual Phonations.

Introduction: There is no normative voice dataset for Japanese speakers in the English literature. We constructed age- and gender-stratified normative voice data with the assistance of vocally healthy Japanese speakers.

Methods: A total of 111 vocally healthy Japanese speakers (42 men, 69 women) were divided into young (13 men, 30 women), middle-aged (18 men, 27 women), and elderly (11 men, 12 women) groups.

Multivariate Analysis of Vocal Fold Vibrations in Normal Speakers Using High-Speed Digital Imaging.

Introduction: Little is known about the normal variations in vocal fold vibrations. We conducted a prospective study on normal subjects using high-speed digital imaging (HSDI) to elucidate key parameters regarding age/gender-related normal variations.

Methods: Forty-six healthy adult volunteers were divided into young (aged ≤35 years) male, young female, elderly (aged ≥65 years) male, and elderly female subgroups.

Characterization of Vocal Fold Vibration in Sulcus Vocalis Using High-Speed Digital Imaging.

Purpose: The aim of the present study was to qualitatively and quantitatively characterize vocal fold vibrations in sulcus vocalis by high-speed digital imaging (HSDI) and to clarify the correlations between HSDI-derived parameters and traditional vocal parameters.

Method: HSDI was performed in 20 vocally healthy subjects (8 men and 12 women) and 41 patients with sulcus vocalis (33 men and 8 women). Then HSDI data were evaluated by assessing the visual-perceptual rating, digital kymography, and glottal area waveform.

High-speed Videolaryngoscopy: Quantitative Parameters of Glottal Area Waveforms and High-speed Kymography in Healthy Individuals.

Objectives: We conducted a study to obtain quantitative parameters of the vocal dynamic using high-speed videolaryngoscopy and to characterize the vocal fold vibration pattern of healthy individuals by analyzing glottal area waveforms and high-speed kymography.

Methods: Laryngeal images of 45 healthy individuals were captured using high-speed videolaryngoscopy. The open and speed quotients of the glottal area waveforms and high-speed kymography were obtained and statistically analyzed according to the gender of each individual.

Quantitative Analysis of Vocal Fold Vibration in Vocal Fold Paralysis With the Use of High-speed Digital Imaging.

Introduction: The goal of this work was to objectively elucidate the vibratory characteristics of vocal fold paralysis (VFP) using high-speed digital imaging (HSDI).

Methods: HSDI was performed in 29 vocally healthy subjects (12 women and 17 men) and in 107 patients with VFP (40 women and 67 men). Then, the HSDI data were evaluated by visual-perceptual rating, single-line kymography, multiline kymography, laryngotopography, and glottal area waveform analysis.

Visualization and Estimation of Vibratory Disturbance in Vocal Fold Scar Using High-Speed Digital Imaging.

Objective: To explore the method to visualize and quantify the abnormality of vocal fold vibration in vocal fold scar (VFS) using high-speed digital imaging (HSDI).

Methods: HSDI was performed on 12 patients (2 men and 10 women) with VFS and 46 vocally healthy subjects (17 men and 29 women), and the obtained data were quantitatively evaluated by frame-by-frame analysis, laryngotopography (LTG), single-line and multiline kymography, and glottal area waveform.

Results: Visualization of a scarred area was feasible in 75% of VFS in the present study using LTG.

Quantification of Vocal Fold Vibration in Various Laryngeal Disorders Using High-Speed Digital Imaging.

Objective: To quantify vibratory characteristics of various laryngeal disorders seen by high-speed digital imaging (HSDI).

Methods: HSDI was performed on 78 patients with various laryngeal disorders (20 with polyp, 16 with carcinoma, 13 with leukoplakia, 6 with vocal fold nodule, and 33 with others) and 29 vocally healthy subjects. Obtained data were quantitatively evaluated by frame-by-frame analysis, laryngotopography, digital kymography, and glottal area waveform.

Relationship of Various Open Quotients With Acoustic Property, Phonation Types, Fundamental Frequency, and Intensity.

Introduction: In the present study, we examined the relationship between various open quotients (Oqs) and phonation types, fundamental frequency (F0), and intensity by multivariate linear regression analysis (MVA) to determine which Oq best reflects vocal fold vibratory characteristics.

Methods: Using high-speed digital imaging (HSDI), a sustained vowel /e/ at different phonation types, F0s, and intensities was recorded from six vocally healthy male volunteers: the types of phonation included modal, falsetto, modal breathy, and modal pressed phonations; and each phonation was performed at different F0s and intensities. Electroglottography (EGG) and sound signals were simultaneously recorded with HSDI.

Vocal Fold Vibration in Vocal Fold Atrophy: Quantitative Analysis With High-Speed Digital Imaging.

Introduction: Vocal fold vibrations of vocal fold atrophy (VFA), a rapidly increasing voice disorder owing to worldwide societal aging, have not been clarified by high-speed digital imaging (HSDI).

Methods: The HSDI method was performed on 46 patients (33 males and 13 females) with VFA and 20 vocally healthy subjects (8 males and 12 females), and the obtained data were quantitatively evaluated by frame-by-frame analysis, laryngotopography, single- and multi-line kymography, and glottal area waveform.

Results: Overall, patients with VFA revealed larger open quotients, larger lateral phase difference, larger integral glottal width (the average glottal width over a glottal cycle), and smaller speed index than vocally healthy subjects.

Quantitative analysis of digital videokymography: a preliminary study on age- and gender-related difference of vocal fold vibration in normal speakers.

Introduction: Kymography is an effective method for assessing temporal patterns of vocal fold vibrations. Because kymographic data for a number of normal speakers based on high-speed digital imaging (HSDI) were limited in the literature, this prospective study was conducted to provide normative kymographic HSDI data and clarify gender- and age-related normal variations.

Methods: Vocally healthy adults were divided into young (≤35 years) and elderly groups (≥65 years).

Age- and gender-related difference of vocal fold vibration and glottal configuration in normal speakers: analysis with glottal area waveform.

Introduction: Glottal area waveform (GAW) analysis is widely used in the assessment of vocal fold vibration by high-speed digital imaging (HSDI). Because normative GAW data obtained from a large number of subjects have not been reported, we conducted a prospective study to obtain normative results for GAW analysis of HSDI findings and clarify normal variations associated with gender and age.

Methods: Vocally healthy adults were divided into a young group (aged ≤ 35 years) and an elderly group (aged ≥ 65 years).

Characteristics of vocal fold vibrations in vocally healthy subjects: analysis with multi-line kymography.

PURPOSE In this study, the authors aimed to analyze longitudinal data from high-speed digital images in normative subjects using multi-line kymography. METHOD Vocally healthy subjects were divided into young (9 men and 17 women; Mage = 27 years) and older groups (8 men and 12 women; Mage = 73 years). From high-speed digital images of phonation at a conversational frequency kymograms were created at 5 different levels of the vocal fold and were analyzed to determine the opening/closing longitudinal phase difference, open quotient, and speed index.

Phase difference of vocally healthy subjects in high-speed digital imaging analyzed with laryngotopography.

Background: To elucidate the vibratory patterns of the vocal folds in normophonic subjects, we conducted a prospective study with laryngotopography, an analyzing technique for high-speed digital imaging to intuitively grasp spatial characteristics of vocal fold vibrations by pixel-wise discrete Fourier transform for brightness curve.

Materials And Methods: Vocally healthy volunteer subjects with neither vocal complaint nor history of laryngeal diseases were divided into young (aged 35 years and younger) and elderly groups (aged 65 years and older), and high-speed digital images of phonations at a conversational frequency were analyzed with laryngotopography: phase differences (PDs) in the anterior-posterior (longitudinal) direction and in the left-right (lateral) direction were assessed.

Results: Twenty-six young subjects (nine men and 17 women with a mean age of 27 years) and 20 elderly subjects (eight men and 12 women with a mean age of 73 years) were assigned to our study.

Evaluation of vocal fold vibration with an assessment form for high-speed digital imaging: comparative study between healthy young and elderly subjects.

Objectives/study Design: We conducted a prospective study with a subjective assessment form for high-speed digital imaging (HSDI) to elucidate the features of vocal fold vibrations in vocally healthy subjects and to clarify gender- and age-related differences.

Methods: Healthy adult volunteers participated in this study. They were divided into young (aged 35 and younger) and elderly (aged 65 and older) groups, and the scores of an assessment form for HSDI characteristics elaborated at our institution were statistically analyzed.

Arytenoid adduction for correcting vocal fold asymmetry: high-speed imaging.

Objectives: We hypothesized that high-speed digital imaging provides a quantitative method to evaluate the effect of arytenoid adduction for the correction of asymmetric and irregular vocal fold vibration in unilateral vocal fold paralysis.

Methods: Six subjects with unilateral vocal fold paralysis participated in the study (4 male, 2 female; mean [-SD] age, 52.5 +/- 21.

Collagen injection for correcting vocal fold asymmetry: high-speed imaging.

Objectives: We hypothesized that high-speed digital imaging with videokymographic and laryngotopographic analysis would provide a quantitative method to evaluate the effect of collagen injection for the correction of asymmetric and irregular vocal fold vibration in unilateral vocal fold paralysis.

Methods: Videokymographic and laryngotopographic analysis was performed for high-speed digital recordings of vocal fold vibration for visualizing the glottal vibratory patterns, and for quantifying the frequency of vibration of each vocal fold, respectively, including comparisons between the paralyzed and normal vocal folds before and after surgery. This included prospective observations of 11 subjects with unilateral vocal fold paralysis (4 male, 7 female; mean +/- SD age, 67.

Clinical analysis of presbylarynx--vocal fold atrophy in elderly individuals.

Objective: The proportion of elderly Japanese is increasing significantly and aging society greatly influences the medical services. The number of elderly patients who visited out Voice Outpatient Clinic has been increasing in recent years. The aim of the present study was to analyze the trend in the number of patients with aging-related vocal fold atrophy, and to assess the characteristics of senile change of vocal function.

Clinical experience with collagen injection of the vocal fold: a study of 155 patients.

Objective: This study evaluated the results of laryngeal collagen injection.

Study Design: Retrospective study of patients who had undergone laryngeal collagen injection.

Materials And Methods: A retrospective review of 275 patients treated with collagen injection and a review of the relevant literature on the results of treatment were presented.

High-speed digital imaging and electroglottography of tracheoesophageal phonation by Amatsu's method.

Background: Our previous findings have indicated that the thyropharyngeal muscles form a retropharyngeal prominence during alaryngeal phonation via the TE fistula. This prominence forms a so-called 'neoglottis', which is thought to function as the vibratory source. To better understand the mechanism of TE phonation, we analyzed the vibration of the neoglottis using electroglottography (EGG) and a high-speed digital imaging system.

Towards the molecular dissection of fertilization signaling: Our functional genomic/proteomic strategies.

Recent advances in DNA sequencing techniques and automated informatics has led to clarification of all genome sequence of some model organisms in a very short period. The demonstration of the first draft sequence of the human genome has prompted us to elaborate new approaches in biology, pharmacology and medicine. Such new research will focus on high throughput methods to function on collections of genes, and hopefully, on a genome-wide, quantitative modeling of the cell system as a whole.