Dynamic planar scintigraphy for the rapid kinetic measurement of myocardial I-MIBG turnover can identify Lewy body disease.

Background: Using two static scans for I-meta-iodobenzyl-guanidine (I-MIBG) myocardial scintigraphy ignores the dynamic response from vesicular trapping in nerve terminals. Moreover, the long pause between scans is impractical for patients with Lewy body diseases (LBDs). Here, we optimized indices that capture norepinephrine kinetics, tested their diagnostic performance, and determined the differences in I-MIBG performance among disease groups.