Publications by authors named "Ken Zafren"

Management of the airway in austere environments can differ substantially from standard in-hospital airway management. Devices such as nasopharyngeal airways, oropharyngeal airways, endotracheal tubes, extraglottic airways, ventilators, and sedative and paralytic medications may not be available. Weather, scene hazards, difficulties of extrication, transport times, skill sets of rescuers, and availability of advanced equipment are highly variable.

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  • The study examines critically buried avalanche victims with cardiac arrest, emphasizing that a noncompressible chest wall or frozen body usually prevents CPR initiation, though the supporting evidence is weak.
  • A retrospective analysis of 53 avalanche victims declared dead from 2010-2019 revealed that 23% had noncompressible chest walls, which were linked to longer burial times and lower body temperatures.
  • The findings suggest that the presence of a noncompressible chest wall alone is not enough to confirm death in these cases and that more clinical information is needed for accurate assessments.
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  • - Dr. William J. Mills Jr. is an Alaskan orthopedic surgeon who transformed frostbite treatment protocols, challenging a long-standing approach set by Napoleon's surgeon general in the early 1800s.
  • - After recognizing the limitations of existing methods in his practice, he researched and advocated for rapid warming of frozen body parts, resulting in significant publication contributions in the 1960s that established this as the new standard treatment.
  • - Mills and his team developed a simplified 2-tier classification system for frostbite (superficial and deep) that is still widely used in clinical and non-hospital settings today.
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  • The study investigates the effects of menstrual cycle phase, menopause, and hormone use on acute mountain sickness (AMS) among female trekkers in high-altitude regions of Nepal.
  • Researchers found that factors like menstrual cycle phase and menopause did not significantly influence the occurrence of AMS.
  • The findings suggest that hormonal status, including the use of hormonal contraception or hormone replacement therapy, is not a risk factor for AMS, indicating that women should be included in AMS research regardless of these factors.
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Introduction: Our objective was to perform a systematic review of the outcomes of various frostbite treatments to determine which treatments are effective. We also planned to perform meta-analyses of the outcomes of individual treatments for which suitable data were available.

Main Body: We performed a systematic review and meta-analyses in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.

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To provide guidance to the general public, clinicians, and avalanche professionals about best practices, the Wilderness Medical Society convened an expert panel to revise the evidence-based guidelines for the prevention, rescue, and resuscitation of avalanche and nonavalanche snow burial victims. The original panel authored the Wilderness Medical Society Practice Guidelines for Prevention and Management of Avalanche and Nonavalanche Snow Burial Accidents in 2017. A second panel was convened to update these guidelines and make recommendations based on quality of supporting evidence.

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To provide guidance to clinicians about best practices, the Wilderness Medical Society (WMS) convened an expert panel to develop evidence-based guidelines for prevention, diagnosis, and treatment of acute mountain sickness, high altitude cerebral edema, and high altitude pulmonary edema. Recommendations are graded based on the quality of supporting evidence and the balance between the benefits and risks/burdens according to criteria put forth by the American College of Chest Physicians. The guidelines also provide suggested approaches for managing each form of acute altitude illness that incorporate these recommendations as well as recommendations on how to approach high altitude travel following COVID-19 infection.

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Poudel, Sangeeta, Sandesh Gautam, Purushottam Adhikari, and Ken Zafren. Physiological effects of sildenafil versus placebo at high altitude: a systematic review. .

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Lugnet, Viktor, Miles McDonough, Les Gordon, Mercedes Galindez, Nicolas Mena Reyes, Alison Sheets, Ken Zafren, and Peter Paal. Termination of cardiopulmonary resuscitation in mountain rescue: a scoping review and ICAR MedCom 2023 recommendations. .

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Avalanches have caused injuries and deaths in mountain areas throughout history. We have examined the historical effects of avalanches on communities in the eastern Spanish Pyrenees. Surviving written records began in the year 1444 when an avalanche destroyed the village of Gessa.

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Psychosis is a psychopathological syndrome that can be triggered or caused by exposure to high altitude (HA). Psychosis can occur alone as isolated HA psychosis or can be associated with other mental and often also somatic symptoms as a feature of delirium. Psychosis can also occur as a symptom of high altitude cerebral edema (HACE), a life-threatening condition.

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  • Takotsubo cardiomyopathy is a heart condition that can be triggered by extreme stress, often presenting as temporary left ventricular dysfunction.
  • This case study details a 41-year-old woman who experienced mid-ventricular Takotsubo cardiomyopathy after being completely buried in an avalanche for 30 minutes, leading to hypothermia and heart rhythm issues.
  • After treatment and recovery, both her heart function and psychological condition improved significantly, highlighting the impact of physical and emotional stress combined with hypothermia on heart health.
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We convened an expert panel to develop evidence-based guidelines for the evaluation, treatment, and prevention of nonfreezing cold injuries (NFCIs; trench foot and immersion foot) and warm water immersion injuries (warm water immersion foot and tropical immersion foot) in prehospital and hospital settings. The panel graded the recommendations based on the quality of supporting evidence and the balance between benefits and risks/burdens according to the criteria published by the American College of Chest Physicians. Treatment is more difficult with NFCIs than with warm water immersion injuries.

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  • In 1755, an avalanche in Bergemoletto, Italy, trapped four people and several animals for 37 days, resulting in the survival of three individuals who relied on limited nutrition.
  • The survivors suffered from severe malnutrition and various medical issues, including weakness, changes in taste, and symptoms resembling post-traumatic stress disorder.
  • The aftermath of their rescue involved a slow refeeding process, and it took 1 to 6 weeks for them to regain the ability to walk, highlighting human resilience in extreme conditions.
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Berendsen, Remco R., Peter Bärtsch, Buddha Basnyat, Marc Moritz Berger, Peter Hackett, Andrew M. Luks, Jean-Paul Richalet, Ken Zafren, Bengt Kayser, and the STAK Plenary Group.

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We present a case of an un-roped mountaineer who fell into a crevasse during descent from the summit of Denali (Mount McKinley). He was wedged about 20 m deep in the crevasse for a total of 16 h; this included 4.5 h waiting for a rescue team to arrive, and an 11.

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In Spain, snakebites are uncommon medical emergencies that cause barely 100 hospitalizations annually. Most of the venomous bites are by snakes of the Viperidae family. Venom from Vipera snakes is reported to have cytotoxic and hematotoxic effects, and neurological effects have also been described.

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