Publications by authors named "Ken Thummel"
We use prescription of statin medications and prescription of warfarin to explore the capacity of electronic health record data to (1) describe cohorts of patients prescribed these medications and (2) identify cohorts of patients with evidence of adverse events related to prescription of these medications. This study was conducted in the WWAMI region Practice and Research Network (WPRN)., a network of primary care practices across Washington, Wyoming, Alaska, Montana and Idaho DataQUEST, an electronic data-sharing infrastructure.
View Article and Find Full Text PDFObjectives: To determine whether antidepressant use is associated with dementia risk.
Design: Prospective cohort study.
Setting: Kaiser Permanente Washington (KPWA), an integrated healthcare delivery system.
Renal function generally is assessed by measurement of GFR and urinary albumin excretion. Other intrinsic kidney functions, such as proximal tubular secretion, typically are not quantified. Tubular secretion of solutes is more efficient than glomerular filtration and a major mechanism for renal drug elimination, suggesting important clinical consequences of secretion dysfunction.
View Article and Find Full Text PDFArticle Synopsis
- The study identified genetic factors that influence liver gene expression by analyzing tissue samples and correlating them with genetic data from different sources.
- About 30% of genetic correlations failed to replicate across studies, highlighting the significant impact of various factors including drug exposure and tissue analysis methods on gene expression results.
- The research discovered numerous liver eQTLs, some of which connect to complex traits and diseases, revealing potential new insights into conditions like diabetes, drug response, and cancer risk.
Objective: The purpose of our study was to evaluate the evidence on the prevalence of cytochrome P450 enzyme polymorphisms as potential genetic factors influencing drug efficacy and safety in the indigenous populations of the American hemispheres.
Methods: We conducted a systematic review of studies published between 1985 and 2006 using the Pubmed database.
Results: We identified only 10 original research studies on CYP2A6, CYP2D6, CYP2C9, CYP2C19 and CYP2E1 in 13 indigenous American populations.