Publications by authors named "Ken Takami"

Background: Malpositioning of the acetabular cup during total hip arthroplasty (THA) can lead to complications. Robotic surgery and navigation techniques aim to address this issue, but there is limited evidence regarding which method can achieve better clinical outcomes. Therefore, this network meta-analysis (NMA) aimed to compare the efficacy of various navigation methods.

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Article Synopsis
  • Oral disulfiram (DSF), traditionally used for alcohol dependence, shows potential antitumor activity, and a transdermal delivery system could improve its administration for cancer treatment.
  • The study assessed the effects of combining oleic acid (OA) and Tween 80 on the skin's ability to absorb DSF, utilizing hairless mouse skin and various ratios of the two compounds.
  • Results indicated that the combination of OA and Tween 80 significantly enhances DSF absorption, with OA increasing the fluidity of skin lipids and Tween 80 enhancing DSF solubility, providing insights for developing an effective transdermal DSF preparation.
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Background: Varicella-zoster virus (VZV) generally causes chickenpox at first infection in childhood and then establishes latent infection in the dorsal root ganglia of the spinal cord or other nerves. Virus reactivation owing to an impaired immune system causes inflammation along spinal nerves from the affected spinal segment, leading to skin manifestations (herpes zoster). Viremia and subsequent hematogenous transmission and nerve axonal transport of the virus may lead to meningitis, encephalitis, and myelitis.

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Iguratimod is a novel disease-modifying antirheumatic drug. A blue letter (safety advisory) for drug interaction between iguratimod and warfarin was issued by the Ministry of Health, Labour and Welfare of Japan in May 2013. Iguratimod may affect warfarin metabolism catalyzed by CYP.

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