Duration Mismatch Negativity in Adults With Autism Spectrum Disorder Versus Healthy Controls.

Objective: The mismatch negativity (MMN) reflects automatic cognitive function in response to auditory stimulation. The MMN to duration deviant (d-MMN) amplitude is known to be lower in children with autism spectrum disorder (ASD) than in healthy controls (HCs). Moreover, the d-MMN is known to be a trait maker of schizophrenia because it is unaffected by the duration of illness.

Abnormal Temporal Window of Integration in Auditory Sensory Memory in Schizophrenia.

Mismatch negativity (MMN) is automatically elicited by incoming sound deviation compared to the neural representation of preceding homogenous sounds stored in the brain's auditory sensory memory. This study aimed to assess time-functional deviation sensitivity in auditory sensory memory associated with a temporal window of integration (TWI) of 160-170 msec in patients with schizophrenia. To this end, we measured the magnetic counterpart of the MMN (MMNm) in 20 patients with schizophrenia on medication and 20 healthy age-matched adults as a control group responding to an omitted tone segment incorporated into a complex sound of 176 ms duration corresponding to the TWI duration.

Differential expression of a stress-regulated gene Nr4a2 characterizes early- and late-born hippocampal granule cells.

Neural progenitors acquire GFAP expression during the perinatal period and continue to generate granule cells (GCs) in the hippocampal dentate gyrus throughout adulthood. Cellular characteristics of GFAP+ progenitor-derived late-born GCs in comparison with early-born GCs remain unknown. Using genetic fate mapping in mice, we show that early- and late-born GCs are concentrated in the outer and inner side of the GC layer, respectively.

The utility of FDG-PET/CT imaging in the evaluation of multicentric reticulohistiocytosis: A case report.

Introduction: Multicentric reticulohistiocytosis (MRH) is a rare histiocytic disorder that involves the skin, joints, and visceral organs.

Case Presentation: We report a 67-year-old woman with MRH who presented with a 2-years history of polyarthralgia and skin nodules. Her symptoms were an inflammatory polyarthropathy with punched-out lesions of the distal interphalangeal (DIP) joints of both hands.