Publications by authors named "Ken Shiraiwa"
Article Synopsis
- Oita University Hospital transitioned from brand-name pemetrexed (PEM) to generic versions and studied the efficiency and safety of this switch.
- The study revealed that generic PEM preparation took significantly less time (0.17 seconds) compared to brand-name PEM (0.34 seconds), making it more efficient.
- No serious adverse effects were reported in patients switched to the generic drug, and the hospital experienced a financial benefit of over 7 million yen, indicating that the switch is both safe and economically advantageous.
Background: Although lenvatinib treatment has a favorable efficacy for unresectable hepatocellular carcinoma (HCC), it is associated with adverse events (AEs) that must be closely monitored and managed. Thrombocytopenia is one of the major AEs. The aim of this study was to clarify whether thrombocytopenia can be predicted by the plasma concentration of lenvatinib.
View Article and Find Full Text PDFWhat Is Known And Objective: Clinical cases of attenuation of opioid analgesic effect by administration of immune checkpoint inhibitors has not been reported. We present a case of head and neck cancer under pain management with opioids, in which cancer pain was exacerbated after administration of nivolumab.
Case Summary: A male patient with head and neck cancer was hospitalized for the second-line treatment of nivolumab.
Article Synopsis
- - Lenvatinib is becoming a common first-line treatment for unresectable hepatocellular carcinoma but is often discontinued due to side effects, primarily because its dosing is based solely on body weight despite significant variation among individuals.
- - A new high-throughput method using ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS) was developed to quantify lenvatinib levels in plasma, aiming to improve how doses are tailored for patients.
- - The method meets FDA validation standards, showing reliable accuracy and precision, and has been successfully tested on blood samples from HCC patients, paving the way for more individualized treatment strategies.
Article Synopsis
- Pazopanib is commonly used in Japan for treating renal cell carcinomas and soft tissue tumors, but measuring only total drug concentration may not provide the best clinical insights due to its high protein binding.
- This study developed a new high-throughput method using ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS) to quantify free pazopanib in human plasma.
- The method meets FDA guidelines and has shown reliable results in measuring free pazopanib concentrations, indicating potential for improving therapeutic drug monitoring for patients undergoing pazopanib treatment.
Drug-drug interaction of fluorinated pyrimidine anticancer agents with phenytoin is well known, but interaction with phenobarbital is limited. We describe a case showing increases in plasma phenobarbital as well as phenytoin concentrations during preoperative S-1 (tegafur/gimeracil/oteracil) and radiation therapy for rectal cancer.
View Article and Find Full Text PDFCombination therapy of tegafur/uracil (UFT) and leucovorin (LV) is widely used to treat colorectal cancers. Although this therapy has a significant therapeutic effect, severe adverse effects occur frequently. Therapeutic drug monitoring (TDM) may help to prevent adverse effects.
View Article and Find Full Text PDFArticle Synopsis
- Pazopanib is commonly used in Japan for treating renal cell carcinomas and soft tissue tumors but can cause severe side effects; therapeutic drug monitoring (TDM) may help manage these issues.
- Researchers developed a high-throughput method using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) to quickly measure pazopanib levels in human plasma.
- The new assay meets FDA and EMA guidelines, demonstrates high precision and accuracy, and has been successfully applied in TDM for patients undergoing treatment with pazopanib.
Background: Chemotherapy after hepatectomy for colorectal liver metastasis has not been established, due to the toxic side effects, which are likely related to impaired drug clearance during liver regeneration. We investigated the pharmacokinetic and toxicodynamic evaluation of 5-fluorouracil (5-FU) during liver regeneration after major hepatectomy in a rat model.
Methods: Thirty-six male Wistar rats were divided into control (C), control with chemotherapy (CC), hepatectomy (H), and hepatectomy with chemotherapy (HC) groups.
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and refractory cancers, and a therapy with a new concept needs to be developed. Recently, research on cancer stem cells (CSCs) has progressed, and CSCs have been suggested to be responsible for metastasis, recurrence, and therapy resistance. In ATC-CSCs, aldehyde dehydrogenase (ALDH) activity is the most reliable marker to enrich CSCs.
View Article and Find Full Text PDFA new benzyl benzoate glycoside and five new 3-deoxy-D-manno-2-octulosonic acid derivatives were isolated from the entire plant of Solidago decurrens together with three known compounds. Their structures were established by extensive analyses of their 1D and 2D NMR spectra and by comparison with physical data of known compounds.
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