Publications by authors named "Ken R Bundell"
Trends Pharmacol Sci
May 2003
Article Synopsis
- Early research on protein transduction domains (PTDs) indicated they could quickly enter cells without needing receptors or endosomes, utilizing domains like those from Tat and Antennapedia.
- Recent studies suggest that this cell uptake is due to the positive charge of PTDs, leading to electrostatic binding to cell membranes followed by endocytosis, rather than direct transport.
- The insights into their uptake mechanisms prompt a reassessment of the effectiveness of PTDs for delivering biological tools in laboratory and living systems.
