A giant peripheral ossifying fibroma of the maxilla with extreme difficulty in clinical differentiation from malignancy: a case report and review of the literature.

Background: Peripheral ossifying fibroma is a nonneoplastic inflammatory hyperplasia that originates in the periodontal ligament or periosteum in response to chronic mechanical irritation. Peripheral ossifying fibroma develops more commonly in young females as a solitary, slow-growing, exophytic nodular mass of the gingiva, no more than 2 cm in diameter. While various synonyms have been used to refer to peripheral ossifying fibroma, very similar names have also been applied to neoplastic diseases that are pathologically distinct from peripheral ossifying fibroma, causing considerable nomenclatural confusion.

Consideration of mouth opening when using positioning stents during radiotherapy for tongue cancer: a retrospective study.

Background: The aim was to clarify the range of mouth opening required to minimize the development of oral mucositis on the palate while using a positioning stent during radiotherapy in patients with tongue cancer. A positioning stent is used to reduce the severity of oral mucositis; however, requirements for fabricating the device have not been standardized. In particular, the range of mouth opening required while using a stent to prevent radiation-induced oral mucositis has not been determined.

Morphological Investigation of Residual Ridge in Japanese Edentulous Elderly for Fabrication of Edentulous Stock Tray.

The objective of this study was to determine the size of the residual ridge in edentulous elderly Japanese persons for preparation of edentulous stock trays and clarify any correlations among the items measured. The participants comprised 74 patients requesting construction of a complete denture for the maxilla, mandible, or both. The length, width, and anterior and posterior height of the maxillary and mandibular residual ridge was measured on a prepared working model using a caliper.

Accuracy and retention of denture base fabricated by heat curing and additive manufacturing.

Purpose: The aim of the present study was to compare the accuracy and retentive force of an experimental denture base fabricated using additive manufacturing and heat curing.

Methods: A maxillary edentulous jaw model made of silicon was used. The shape data for the working cast and wax pattern of the experimental denture base were obtained using a dental laboratory scanner.

Relationship between masticatory function and frailty in community-dwelling Japanese elderly.

Background: Frailty likely results in impaired functioning, and frail individuals requiring long-term care have recently attracted the attention of researchers. In the oral health field, the number of elderly individuals who require intervention for retaining occlusion has been increasing, as has the number of remaining teeth and required prosthetic treatment. Additionally, the number of elderly with reduced masticatory function has also been increasing, and frailty is a suspected factor.

Maxillofacial prosthetic treatment factors affecting oral health-related quality of life after surgery for patients with oral cancer.

Statement Of Problem: After oral cancer surgery, tissue defects can cause deformity and limited mobility, complicating many essential functions. For patients with mandibular, tongue, and oral floor defects, evidence regarding the effects of maxillofacial prosthetics on their oral health-related quality of life (OHRQoL) is lacking. Therefore, maxillofacial prosthetic reconstruction has been implemented with no clear treatment goals.

Anti-infective control in human bronchiolar epithelial cells by mucin phenotypic changes following uptake of N-acetyl-L-cysteine.

Purpose: Aspiration pneumonia is infection of the respiratory tract resulting from accumulation of sputum in the larynx. N-acetyl-L-cysteine (NAC) might regulate mucin (MUC) expression and activate inherent anti-infective system in bronchiolar epithelial cells after cellular uptake, and therefore, serve as the preventative agent for chronic lung disease including aspiration pneumonia. The purpose of this in vitro study was to evaluate the effect of uptake of NAC by human bronchiolar epithelial cells on bacterial infection and regulations of mucin expression in association with cellular redox status under co-culture with a representative pathogen for hospital- and community-acquired pneumonia, Streptococcus pneumoniae.

Ultraviolet-C irradiation to titanium implants increases peri-implant bone formation without impeding mineralization in a rabbit femur model.

Objectives: Volume and bone quality of peri-implant supporting bone, in particular, at implant neck region, as well as bone-implant contact ratio, is important for long-term stability of implants. Ultraviolet-C (UVC) irradiation is known to enhance the osseointegration capability of titanium implants. However, the histological determination was performed only on a rat model, but not pre-clinical animal model such as a rabbit model.

A 5-year activity report from the Oral Cancer Center, Tokyo Dental College.

The Tokyo Dental College Oral Cancer Center was established on April 1st, 2006 at our Ichikawa General Hospital for the purpose of providing multimodal treatment for oral cancer. This report summarizes the Center's activities over the last 5 years. The total number of oral cancer patients treated was 360 (April 2006 to March 2011), with 205 primary cases.

Specific ultraviolet-C irradiation energy for functionalization of titanium surface to increase osteoblastic cellular attachment.

Purpose: The objective of this in vitro study was to examine the influence of the total energy of ultraviolet-C preirradiation on the number and morphology of osteoblastic cells attached to turned or acid-etched titanium surfaces, and physicochemical properties of the surface.

Materials And Methods: Rat bone marrow-derived osteoblasts were incubated with turned or acid-etched titanium disks preirradiated with ultraviolet-C at 1 or 3 mW/cm(2), resulting in total energies of 10, 100, 250, 400, 500, 600, 750, or 1000 J/cm(2). Osteoblast attachment to the surface was evaluated using the WST-1 assay.

Nanometer-thin TiO₂ enhances skeletal muscle cell phenotype and behavior.

Background: The independent role of the surface chemistry of titanium in determining its biological properties is yet to be determined. Although titanium implants are often in contact with muscle tissue, the interaction of muscle cells with titanium is largely unknown. This study tested the hypotheses that the surface chemistry of clinically established microroughened titanium surfaces could be controllably varied by coating with a minimally thin layer of TiO(2) (ideally pico-to-nanometer in thickness) without altering the existing topographical and roughness features, and that the change in superficial chemistry of titanium is effective in improving the biological properties of titanium.

Bone integration capability of alkali- and heat-treated nanobimorphic Ti-15Mo-5Zr-3Al.

The role of nanofeatured titanium surfaces in a number of aspects of in vivo bone-implant integration, and, in particular, their potential advantages over microfeatured titanium surfaces, as well as their specific contribution to osteoconductivity, is largely unknown. This study reports the creation of a unique nanobimorphic titanium surface comprised of nanotrabecular and nanotuft-like structures and determines how the addition of this nanofeature to a microroughened surface affects bone-implant integration. Machined surfaces without microroughness, sandblasted microroughened surfaces, and micro-nano hybrid surfaces created by sandblasting and alkali and heat treatment of Ti-15Mo-5Zr-3Al alloy were subjected to biomechanical, interfacial and histological analyses in a rat model.

Effects of pico-to-nanometer-thin TiO2 coating on the biological properties of microroughened titanium.

The independent, genuine role of surface chemistry in the biological properties of titanium is unknown. Although microtopography has been established as a standard surface feature in osseous titanium implants, unfavorable behavior and reactions of osteogenic cells are still observed on the surfaces. To further enhance the biological properties of microfeatured titanium surfaces, this study tested the hypotheses that (1) the surface chemistry of microroughened titanium surfaces can be controllably varied by coating with a very thin layer of TiO(2), without altering the existing topographical and roughness features; and (2) the change in the surface chemistry affects the biological properties of the titanium substrates.

Influence of anterior palatal coverage on perception and retention in complete dentures.

Statement Of Problem: Oral perception is adversely affected by palatal coverage in complete denture wearers.

Purpose: The purpose of this study was to determine whether an opening in an anterior palatal base enhanced oral perception and the effect of the size of the opening on retention.

Material And Methods: Ten healthy dentate individuals (5 men, 5 women; age range: 22-29 years) participated in the perception test.

Response of Merkel cells in the palatal rugae to the continuous mechanical stimulation by palatal plate.

The aim of the present study was to investigate the responses of Merkel cells that are numerous in the palatine rugae, due to the continuous mechanical stimulation exerted by the palatal plate. Forty golden hamsters were used in this experiment. The palatal plate was made of adhesive resin and it was set on the palate of the animal.

Characterization of the peri-implant epithelium in hamster palatine mucosa: behavior of Merkel cells and nerve endings.

The purpose of this study was to investigate the relationship between Merkel cells and nerve elements during tissue regeneration after receiving dental implants. Golden hamsters were divided into 3 groups and titanium alloy implants were fixed in their left-side maxilla through the third palatine rug. Animals were sacrificed at 1, 2, 3, 4, 5, 6, and 7 days after the implantation and tissues were characterized at the immunohistochemical and morphological levels.