Publications by authors named "Ken Eto"
Article Synopsis
- Histone lactylation is a new epigenetic modification driven by lactate from glycolysis, which is often heightened in cancer, notably gastric cancer (GC), and is linked to poorer patient outcomes.
- In GC, increased levels of histone H3K18 lactylation correlate with worse prognosis, while SIRT1 plays a key role in regulating these levels by either promoting or diminishing H3K18la depending on its expression.
- Targeting the interplay between SIRT1, the lncRNA H19, and glycolysis presents a promising therapeutic approach for GC, showing significant anti-cancer effects while minimizing harm to normal cells.
Introduction And Importance: The importance of preoperative tumor site marking has increased over the years, as the method of intraoperative primary lesion identification and determination of resection margins is one factor determining whether oncological safety and function-preserving gastrectomy are possible during surgery. We hypothesize that preoperative placement of the near-infrared fluorescent (NIRF) clip, ZEOCLIP FS, near the oral incision line of the gastric tumor will allow for Firefly recognition of the NIRF clip on da Vinci during surgery and easy determination of the tumor location and incision line. Hence, we report on two cases in which the procedure was performed.
View Article and Find Full Text PDFObjectives: The prognostic significance of a high visceral fat area (VFA) in metastatic colorectal cancer (mCRC) remains unclear. We evaluated the prognostic impact of high-VFA on the long-term outcomes of patients with mCRC who underwent chemotherapy.
Methods: Ninety patients with metastatic CRC who underwent chemotherapy were included.
Article Synopsis
- The study aimed to compare clinical characteristics and surgical outcomes between para-colostomy hernia (PCH) and para-ileal-conduit hernia (PICH) following laparoscopic repairs using data from 41 cases at Jikei University Daisan Hospital.
- Results indicated no significant differences in patient backgrounds or hernia features, but PICH had a higher rate of severe intra-abdominal adhesions (60% vs. 23%) and longer operation times (223 minutes vs. 158 minutes).
- The findings suggest that PICH repairs are more challenging due to these factors, highlighting the need for separate discussions on surgical outcomes for different types of stomas.
Background: Metastatic gastric tumors are rare and malignant melanoma, breast cancer, lung cancer, and esophageal cancer are common as primary lesions. On the other hand, renal cell carcinoma is easy to metastasize hematogenously to the whole body. However, metastasis to the stomach is rare and the detailed treatment of gastric metastasis is not mentioned.
View Article and Find Full Text PDFPurpose: Laparoscopic sleeve gastrectomy (LSG) drastically affects body composition. However, studies focusing on the association between the changes in the pre-and postoperative muscle mass and postoperative results are limited. We evaluated the association between changes in the muscle mass and weight loss and fat reduction.
View Article and Find Full Text PDFBackground: Sarcopenia affects the postoperative prognosis of patients with colorectal cancer (CRC). Recently, it has become possible to measure psoas volume from computed tomography images, and an index called psoas volume index (PVI) has been reported. However, it is unclear whether the dynamics of PVI before and after surgery is associated with clinical outcomes after CRC surgery.
View Article and Find Full Text PDFObjectives: Laparotomy for lower intestinal perforation is associated with a high incidence of surgical site infections. This study aimed to assess whether incisional negative pressure wound therapy (iNPWT) could reduce the incidence of these infections and wound dehiscence in patients with lower intestinal perforation.
Methods: This single-center prospective study was conducted between September 2019 and July 2022.
Background/aim: This study evaluated the prognostic impact of vertebral fractures (VFs) on the survival of patients with colorectal cancer (CRC).
Patients And Methods: We included 299 patients with stage I-III CRC who had undergone elective surgery. The patients were divided into the VF group (n=94) and non-VF group (n=205).
Article Synopsis
- * Six months after LSG, significant improvements were found in QoL scores, with total weight loss averaging 28.5% and excess weight loss at 79.1%.
- * Although food tolerance decreased slightly, eating satisfaction remained unchanged, suggesting that QoL improves after surgery without negatively affecting the enjoyment of eating.
Background/aim: The purpose of this study was to evaluate the outcomes of the sentinel node navigation surgery (SNNS) followed by limited gastrectomy for early gastric cancer (EGC) with Endoscopic Curability C-2 (eCuraC-2).
Patients And Methods: Between 2001 and 2018, 33 patients were included in this study. Following sentinel node (SN) biopsy using indocyanine green combined with an infrared ray laparoscopic system, limited gastrectomy (LG) [wedge resection (WR), or segmental gastrectomy (SG)] was performed without extended lymphadenectomy.
Purpose: Stoma construction and closure are common surgical strategies in patients with colorectal cancer. The present study evaluated the influence of multiple incisional sites resulting from stoma closure on incisional hernia after colorectal cancer surgery.
Methods: The study included 1681 patients who underwent colorectal cancer surgery.
Purpose: To compare the pathophysiology and surgical outcomes of emergency surgery for upper gastrointestinal tract perforation with and without fungal peritonitis and identify the risk factors for fungal peritonitis.
Methods: The subjects of this retrospective study were patients with upper gastrointestinal perforation and peritonitis who underwent emergency surgery at a single medical center in Japan. The patients were allocated to two groups according to the presence or absence of fungal peritonitis: group F and group N, respectively.
Purpose: Sarcopenia is a prognostic predictor in emergency surgery. However, there are no reports on the relationship between osteopenia and in-hospital mortality. This study clarified the effect of preoperative osteosarcopenia on patients with gastrointestinal perforation after emergency surgery.
View Article and Find Full Text PDFBackground: The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is a novel immuno-nutritional biomarker based on the levels of CRP, serum albumin, and lymphocyte count. This study examined the prognostic value of the CALLY index in patients with colorectal cancer undergoing curative surgery.
Methods: Between 2010 and 2017, 578 patients with stage II-III colorectal cancer who underwent curative resection were enrolled.
Considering the cost and invasiveness of monitoring postoperative minimal residual disease (MRD) of colorectal cancer (CRC) after adjuvant chemoradiotherapy (ACT), we developed a favorable approach based on methylated circulating tumor DNA to detect MRD after radical resection. Analyzing the public database, we identified the methylated promoter regions of the genes FGD5, GPC6, and MSC. Using digital polymerase chain reaction (dPCR), we termed the "amplicon of methylated sites using a specific enzyme" assay as "AMUSE.
View Article and Find Full Text PDFArticle Synopsis
- * In a case series involving 20 patients, they found that NIRFCs were successfully detected in 85% of cases, although detection rates decreased after preoperative chemoradiation in some patients.
- * The findings suggest that using NIRFCs is a feasible and effective method for guiding rectal cancer surgery, as it showed no adverse events and provided reliable measurements for DRM and lymph node retrieval.
Article Synopsis
- * Roux-en-Y gastric bypass (RYGB) is usually better for severe obesity linked to GERD, but it's not ideal for Japanese patients due to their higher gastric cancer risk and challenges with observing the stomach during endoscopies.
- * A new method combining LSG and Toupet fundoplication (called T-sleeve) was tested and showed promising results in a patient, suggesting it could be a viable treatment for Japanese patients with severe obesity and GERD
Purpose: Systemic inflammatory response markers are reported to be prognostic for patients with cancer. The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index has been established as an immuno-nutritional scoring system. The aim of this study was to clarify the impact of the preoperative CALLY index on the outcome of patients undergoing gastrectomy for gastric cancer.
View Article and Find Full Text PDFBackground: Systemic inflammatory response is significant prognostic indicator in patients with various diseases. The relationship between prognostic scoring systems based on the modified Glasgow Prognostic Score (mGPS) and achalasia in patients treated with laparoscopic Heller‑myotomy with Dor‑fundoplication (LHD) remains uninvestigated. This study aimed to examine the role of mGPS in patients with achalasia.
View Article and Find Full Text PDFArticle Synopsis
- A study evaluated a new tumor marker index (TMI), which combines carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9), to determine its effectiveness in predicting outcomes for colorectal cancer (CRC) patients.
- The research involved 306 patients with stages I-III CRC and showed that those in the high-TMI group had significantly lower 5-year relapse-free survival (RFS) and cancer-specific survival (CSS) rates compared to the low-TMI group.
- Further analysis revealed that factors like advanced tumor stage (≥T3), stage III CRC, and high TMI were significant predictors for worse RFS and CSS, indicating that preoperative TMI can reliably forecast prognosis
Article Synopsis
- - The Japan Society of Endoscopic Surgery (JSES) created a proctoring system in 2019 to help prevent serious injuries during surgery in Japan, specifically for robotic gastrectomy (RG) in hospitals lacking experience with robotic techniques.
- - A clinical study conducted at a single center involved ten patients, where RG was initially supervised by the JSES for the first six cases, and the surgery was performed independently for the last four, all without serious complications (C-D grade IIIa or higher).
- - The findings highlight the importance of mentorship in safely implementing robotic surgery in inexperienced facilities, showing positive results while indicating the need for further studies on RG safety in smaller institutions.
Introduction: Cholinesterase is a classical marker that reflects nutritional and inflammatory status. The aim of the present study was to evaluate the association between serum cholinesterase levels and postoperative infectious complications in patients undergoing gastrectomy for gastric cancer.
Materials And Methods: This retrospective study comprised 108 patients who underwent gastrectomy for gastric cancer.
Purpose: Some prospective trials have demonstrated the feasibility of sentinel node (SN) biopsy in gastric cancer (GC) surgery. This study aimed to identify the appropriate concentration settings for the intraoperative injection of indocyanine green (ICG) for SN biopsy.
Methods: Before the clinical studies, porcine model experiments explored the optimal concentration of ICG injected intraoperatively.
Objective: The prognostic significance of a low visceral fat area (VFA) in colorectal cancer (CRC) remains unclear. The aim of this study was to evaluate the prognostic effects of a low VFA on the long-term outcomes of patients with CRC after laparoscopic surgery.
Methods: This retrospective study included 306 patients with stages I-III CRC who underwent R0 resection.