The Costs of a Multisectoral Nutrition Program Implemented Through a Poultry Value Chain Platform in Burkina Faso.

Undernutrition in women and young children in Burkina Faso is a critical problem. Egg consumption is low despite many households raising poultry. The Soutenir l'Exploitation Familiale pour Lancer l'Élevage des Volailles et Valoriser l'Économie Rurale (SELEVER) project, an integrated agriculture-nutrition intervention, promoted egg consumption and sales to investigate the impact of poultry production on child nutrition.

Scoping review of social workers' professional roles in primary care.

Objectives: Maximising social workers' contributions to primary care requires clarity about their scope of practice in this context. This scoping review sought to clarify what is known about social work's scope of practice in primary care settings.

Design: A scoping review design guided by the five-stage scoping review framework developed by Arksey and O'Malley and the updated JBI Manual for Evidence Synthesis.

An Analysis of School-Based Mental Health Models and Policies.

The youth mental health crisis in the United States was exacerbated by the COVID-19 pandemic, as well as in part by widespread, frequent use of the internet and social media. Schools provide an opportune setting for delivering prompt preventative interventions to actively mitigate this crisis. The purpose of this project was to identify policy recommendations for improving school-based mental health services and reducing inequities in care, as well as to produce guidelines on how to advocate for better policies for school mental health services.

Examining Engagement Calendar Deviations in Assisted Living: A Focus on Residents With Dementia.

Early in our longitudinal qualitative study on meaningful engagement and quality of life among assisted living (AL) residents with dementia, researchers observed differences between the activities scheduled on monthly engagement calendars and those taking place. Yet, we were unable to identify any research examining such deviations or their implications. Thus, drawing on data from three diverse AL communities studied over a one-year period, we aim to: 1) examine deviations in scheduled engagement programming; 2) identify influential factors; and 3) understand resident outcomes.

Word reuse and combination support efficient communication of emerging concepts.

A key function of the lexicon is to express novel concepts as they emerge over time through a process known as lexicalization. The most common lexicalization strategies are the reuse and combination of existing words, but they have typically been studied separately in the areas of word meaning extension and word formation. Here, we offer an information-theoretic account of how both strategies are constrained by a fundamental tradeoff between competing communicative pressures: Word reuse tends to preserve the average length of word forms at the cost of less precision, while word combination tends to produce more informative words at the expense of greater word length.

Mental Health Risk Assessment and Safety Planning During UK Covid-19 Pandemic Lockdown: Mixed Methods Survey and Interview Study.

Risk assessment and safety planning are central to mental health nursing practice but were seriously affected by the Covid-19 pandemic and associated lockdowns. In this study, we aimed to explore how the UK pandemic lockdowns affected risk assessment and safety planning from the perspective of mental health practitioners. A sequential, mixed methods study design was used.

Effects of different feeding strategies on behavior and performance in broiler breeder pullets.

This study examined the effects of different feeding strategies (diluted diets and feeding frequency) on the behavior and performance of broiler breeder pullets. A total of 3,200 1-day-old female pullets (Ross 308) were randomly distributed over 16 floor pens in 4 rooms and allocated to 1 of 4 treatments: (1) control diet once a day (CON), (2) 20% diluted diet once a day (20-ON), (3) 20% diluted diet twice a day (20-TW), and (4) 30% diluted diet twice a day (30-TW). All the pullets of the different treatments were fed to the same body weight (BW) profile.

Exploring preparedness transitions in medicine and pharmacy: a qualitative longitudinal study to inform multiprofessional learning opportunities.

Despite extensive preparedness literature, existing studies fail to adequately explore healthcare graduates' feelings of preparedness longitudinally across new graduate transition journeys, nor do they compare different healthcare professions to ascertain what opportunities exist for multiprofessional transition interventions. Therefore, this Australian study, underpinned by temporal theory, explores the preparedness transitions of medicine and pharmacy graduates. Our 6-month qualitative longitudinal study involved 12 medicine and 7 pharmacy learners after purposive sampling.

Knowledge graphs facilitate prediction of drug response for acute myeloid leukemia.

Acute myeloid leukemia (AML) is a highly aggressive and heterogeneous disease, underscoring the need for improved therapeutic options and methods to optimally predict responses. With the wealth of available data resources, including clinical features, multiomics analysis, and drug screening from AML patients, development of drug response prediction models has become feasible. Knowledge graphs (KGs) embed the relationships between different entities or features, allowing for explanation of a wide breadth of drug sensitivity and resistance mechanisms.

Restoring Decency to the Care of Undomiciled Foster Youth.

In April 2023, a distinguished panel of scientists, advocates, and child health policy experts convened by the American Enterprise Institute (AEI) issued a report entitled, "Why Foster Children Are Sleeping in Offices and What We Can Do About It." It concluded that the 2018 Family First Prevention Services Act (FFPSA), which was intended to protect children and adolescents from hazards of institutional care, precipitated a cascade of unintended consequences resulting in large numbers of foster children and adolescents with higher levels of need living in a range of inappropriate settings, including child welfare offices, emergency rooms, hotels, and homeless shelters. Across the United States, FFPSA resulted in severe shortages of placement options for undomiciled foster youth, which were precipitated by constraints in the following: (1) resources, (2) qualifications for reimbursement eligibility, and (3) numbers of beds (by broad extension of the institutions for mental disease [IMD] exclusion in Medicaid restricting bed capacity to 16) for congregate care settings that could otherwise be providing compassionate, qualified, appropriate care to this vulnerable population.

Aripiprazole/Sertraline Combination: Clinical and Cost-Effectiveness in Comparison With Quetiapine for the Treatment of Bipolar Depression (ASCEnD Trial)-Protocol for a Nested Qualitative Study.

Introduction: Bipolar disorder is a recurrent mental health disorder with a prevalence rate of 1.4%. On average, there can be a delay of 9.

Implementation Science for HIV Prevention and Treatment in Indigenous Communities: a Systematic Review and Commentary.

Purpose Of Review: We systematically reviewed implementation research conducted in Indigenous communities in the Americas and the Pacific that focused on improving delivery of HIV preventive or treatment services. We highlight strengths and opportunities in the literature and outline principles for Indigenous-led, HIV-related implementation science.

Recent Findings: We identified 31 studies, revealing a consistent emphasis on cultural tailoring of services to Indigenous communities.

Implementation strategies to improve HIV care cascade outcomes in low- and middle-income countries: a systematic review from 2014 to 2021.

Introduction: In low- and middle-income countries (LMICs), which are disproportionately affected by the HIV epidemic and manage limited resources, optimized implementation strategies are needed to enhance the efficiency of the HIV response. Assessing strategy usage to date could identify research gaps and inform future implementation efforts. We conducted a systematic review to describe the features and distributions of published implementation strategies attempting to improve HIV treatment service delivery and outcomes.

AAV9-Mediated Intrastriatal Delivery of Reduces Hyperlocomotion in Heterozygous R209H Mutant Mice.

Mutations in the gene, which encodes the abundant brain G-protein G , result in neurologic disorders characterized by developmental delay, epilepsy, and movement abnormalities. There are over 50 mutant alleles associated with disorders; the R209H mutation results in dystonia, choreoathetosis, and developmental delay without seizures. Mice heterozygous for the human mutant allele ( ) exhibit hyperactivity in open field tests but no seizures.

A qualitative examination of the experiences and perspectives of interprofessional primary health care teams in the distribution of the COVID-19 vaccination in Ontario, Canada.

Background: Primary health care (PHC) teams contributed to all phases of the COVID-19 vaccination distribution. However, there has been criticism for not fully utilizing the expertise and infrastructure of PHC teams for vaccination distribution. Our study sought to understand the role PHC teams had in the distribution of the COVID-19 vaccine in Ontario, Canada.

Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer's disease: a randomized, controlled clinical trial.

Background: Evidence links lifestyle factors with Alzheimer's disease (AD). We report the first randomized, controlled clinical trial to determine if intensive lifestyle changes may beneficially affect the progression of mild cognitive impairment (MCI) or early dementia due to AD.

Methods: A 1:1 multicenter randomized controlled phase 2 trial, ages 45-90 with MCI or early dementia due to AD and a Montreal Cognitive Assessment (MoCA) score of 18 or higher.

Person-centred interventions to improve patient-provider relationships for HIV services in low- and middle-income countries: a systematic review.

Introduction: Person-centred care (PCC) has been recognized as a critical element in delivering quality and responsive health services. The patient-provider relationship, conceptualized at the core of PCC in multiple models, remains largely unexamined in HIV care. We conducted a systematic review to better understand the types of PCC interventions implemented to improve patient-provider interactions and how these interventions have improved HIV care continuum outcomes and person-reported outcomes (PROs) among people living with HIV in low- and middle-income countries.

The costs of Suaahara II, a complex scaled-up multisectoral nutrition programme in Nepal.

Limited evidence exists on the costs of scaled-up multisectoral nutrition programmes. Such evidence is crucial to assess intervention value and affordability. Evidence is also lacking on the opportunity costs of implementers and participants engaging in community-level interventions.

Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition.

Background: Parkinson's disease (PD) is a neurodegenerative disorder that is characterized by the presence of proteinaceous alpha-synuclein (α-syn) inclusions (Lewy bodies), markers of neuroinflammation and the progressive loss of nigrostriatal dopamine (DA) neurons. These pathological features can be recapitulated in vivo using the α-syn preformed fibril (PFF) model of synucleinopathy. We have previously determined that microglia proximal to PFF-induced nigral α-syn inclusions increase in soma size, upregulate major-histocompatibility complex-II (MHC-II) expression, and increase expression of a suite of inflammation-associated transcripts.

Cumulative exposure to depressive symptoms and all-cause mortality among adults with HIV in Kenya, Nigeria, Tanzania, and Uganda.

Objective: We estimated the effects of cumulative exposure to depressive symptoms on risk of all-cause mortality among people with HIV (PWH) in four African countries.

Design: An analysis of prospective cohort data.

Methods: The African Cohort Study (AFRICOS) is a prospective cohort of people receiving care at twelve clinics in Kenya, Nigeria, Tanzania, and Uganda.

Genetic parameters for carcass traits of progeny of beef bulls mated to dairy cows.

Beef × dairy crossbred cattle (n = 615) were used to evaluate the effect of preharvest indicator traits and genotypes on the accuracy of estimated breeding values (EBVs) of seedstock candidates for selection. Genotypes for 100,000 single nucleotide polymorphisms were provided by the American Simmental Association of purebred and crossbred seedstock animals (n = 2,632). Five hundred and ninety-five of the 615 beef × dairy cattle had carcass camera and ultrasound data.

A qualitative examination of primary care team's participation in the distribution of the COVID-19 vaccination.

Background: Primary health care (PHC) has historically led and implemented successful immunization programs, driven by strong relationships with patients and communities. During the COVID-19 pandemic, Canada began its vaccination strategy with mass immunizations that later included local efforts with PHC providers. This study seeks to understand how PHC contributed to the different phases of the COVID-19 vaccination rollouts in Ontario, Canada's most populous province.