Development of a Lateral Flow Strip with a Positive Readout for the On-Site Detection of Aflatoxin B.

Aflatoxin B is one of the contamination indicators for food safety monitoring. The rapid and effective assessment and determination of AFB in food is of great importance to dietary safety. The lateral flow assay shows advantages in its simplicity, and rapidity, and provides a visual readout, while the available lateral flow assay for AFB requires a competitive format that produces readings inversely proportional to the AFB concentration, which is counterintuitive and may lead to a potential misinterpretation of the results.

Aptamer based surface plasma resonance assay for direct detection of neuron specific enolase and progastrin-releasing peptide (31-98).

Neuron specific enolase (NSE) and progastrin-releasing peptide (31-98) (ProGRP31-98) are considered as reliable biomarkers of small cell lung cancer (SCLC). Sensitive determinations of NSE and ProGRP31-98 show great significance in disease surveillance, clinical diagnosis, efficacy evaluation and prognostic judgment. However, the conventional detection methods have the disadvantages of poor stability, tedious operation, and being very time consuming.

Discovery of Novel 2,4-Dianilinopyrimidine Derivatives Containing 4-(Morpholinomethyl)phenyl and -Substituted Benzamides as Potential FAK Inhibitors and Anticancer Agents.

Focal adhesion kinase (FAK) is responsible for the development and progression of various malignancies. With the aim to explore novel FAK inhibitors as anticancer agents, a series of 2,4-dianilinopyrimidine derivatives - and - containing 4-(morpholinomethyl)phenyl and -substituted benzamides have been designed and synthesized. Among them, compound displayed potent anti-FAK activity (IC = 0.