Highly Chemoselective Synthesis of α, α-Dideuterio Amines by the Reductive Deuteration of Thioamides Using Mild SmI-DO.

An efficient and chemoselective protocol for the single-electron-transfer (SET) reductive deuteration of thioamides using SmI and DO is reported. This method uniquely produces α,α-dideuterio amines via a thio-ketyl radical intermediate without generating alcohol byproducts, distinguishing it from the SET reduction of amides. The inherent high reactivity of thioamides obviates the need for ligands like EtN to improve the reducing power of SmI, thereby enabling milder reaction conditions that are compatible with a broad range of sensitive functional groups.

Prognostic value of neutrophil to lymphocyte ratio and platelet counts during chemotherapy in patients with advanced gastric cancer.

Objectives: To investigate the predictive significance of dynamic changes in the neutrophil to lymphocyte ratio (NLR) and platelet counts (PLTs) in patients with advanced gastric cancer (GC) during chemotherapy.

Methods: A total of 259 advanced GC patients receiving chemotherapy were enrolled and grouped by high or low NLR with a cut value of 2.5 and PLT with cut value of 300×10/L.

Active terahertz beam steering based on mechanical deformation of liquid crystal elastomer metasurface.

Active metasurfaces are emerging as the core of next-generation optical devices with their tunable optical responses and flat-compact topography. Especially for the terahertz band, active metasurfaces have been developed as fascinating devices for optical chopping and compressive sensing imaging. However, performance regulation by changing the dielectric parameters of the integrated functional materials exhibits severe limitations and parasitic losses.

Terahertz metasurface with multiple BICs/QBICs based on a split ring resonator.

Bound state in the continuum (BIC) refers to the trapped state in the radiation continuum of a system. In the terahertz band, BIC provides a unique and feasible method to design devices with ultra-high quality factor (Q factor) and to achieve intense terahertz-matter interaction, which is of great value to terahertz science and technology. Here, multiple BICs protected by the resonance symmetry in the terahertz metasurface consisting of metallic split ring resonators (SRR) is demonstrated.

Effects of alendronate sodium combined with InterTan on osteoporotic femoral intertrochanteric fractures and fracture recurrence.

Background: Osteoporosis is a global disease affecting 6.6% of the total population. Osteoporosis complications include fractures, increased bone fragility, and reduced bone strength.

Synergistic effect of novel Co-modified micro/nano geopolymers in a photo-PDS system.

Persulfate activation is an efficient advanced oxidation process for water treatment. However, many catalyst materials make their preparation methods and raw materials very complicated and expensive while pursuing high-efficiency catalytic effects. In this research, a novel Co-modified micro/nano geopolymer (Co-MNG) material was prepared from solid waste using a mechanochemical method.

Moisture-resistant and green cyclodextrin metal-organic framework nanozyme based on cross-linkage for visible detection of cellular hydrogen peroxide.

A moisture-resistant and green cyclodextrin metal-organic framework (CD-MOF) nanosheet has been prepared via an one-pot antisolvent synthesis procedure. After the treatment of in situ chemical cross-linkage, the two-dimensional (2D) cross-linked CD-MOF exhibited both peroxidase (POD) and oxidase (OXD) enzymatic activities, as well as hydrolytic stability. On the basis of its POD mimics function, the proof-of-concept biosensors were constructed to realize the colorimetric detection for HO and glucose, respectively.

All-dielectric nanograting for increasing terahertz radiation power of photoconductive antennas.

Photoconductive antenna (PCA) is a widely used terahertz (THz) radiation source, but its low radiated power limits the signal-to-noise ratio and bandwidth in THz imaging and spectroscopy applications. Here, we achieved significant PCA power enhancement through etching nanograting directly on the surface of the PCA substrate. The integrated nanograting not only maximizes the generation of photocarriers, but also benefits the bias electric field loaded on the photocarriers.

CTX-M β-lactamase-producing Klebsiella pneumoniae in suburban New York City, New York, USA.

CTX-M extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae isolates are infrequently reported in the United States. In this study, we analyzed nonduplicate ESBL-producing K. pneumoniae and Escherichia coli clinical isolates collected during 2005-2012 at a tertiary care medical center in suburban New York City, USA, for the presence of blaCTX-M, blaSHV, blaTEM, and blaKPC genes.

Inhibition of miR-205 impairs the wound-healing process in human corneal epithelial cells by targeting KIR4.1 (KCNJ10).

Purpose: The aim of the study was to test the hypotheses that injury stimulates the expression of miR-205, which in turn inhibits KCNJ10 channels by targeting its 3' UTR, thereby facilitating the wound-healing process in human corneal epithelial cells (HCECs).

Methods: A stem-loop qRT-PCR was used to examine the miR-205 expression. BrdU cell proliferation assay and wound scratch assay were applied to measure the effect of miR-205 mimic or antagomer in HCECs.

Src family protein tyrosine kinase regulates the basolateral K channel in the distal convoluted tubule (DCT) by phosphorylation of KCNJ10 protein.

The loss of function of the basolateral K channels in the distal nephron causes electrolyte imbalance. The aim of this study is to examine the role of Src family protein tyrosine kinase (SFK) in regulating K channels in the basolateral membrane of the mouse initial distal convoluted tubule (DCT1). Single-channel recordings confirmed that the 40-picosiemen (pS) K channel was the only type of K channel in the basolateral membrane of DCT1.

Detection of Borrelia burgdorferi nucleic acids after antibiotic treatment does not confirm viability.

The persistence of dormant, noncultivable Borrelia burgdorferi after ceftriaxone treatment was examined. B. burgdorferi isolates were cultivated in Barbour-Stoenner-Kelly medium in the presence or absence of ceftriaxone, and cultures were monitored for up to 56 days.

CD19: a biomarker for B cell development, lymphoma diagnosis and therapy.

The human CD19 antigen is a 95 kd transmembrane glycoprotein belonging to the immunoglobulin superfamily. CD19 is classified as a type I transmembrane protein, with a single transmembrane domain, a cytoplasmic C-terminus, and extracellular N-terminus. CD19 is a biomarker for normal and neoplastic B cells, as well as follicular dendritic cells.

Novel CD20 monoclonal antibodies for lymphoma therapy.

Rituximab (RTX), a monoclonal antibody (mAb) against CD20, has been widely used for lymphoma therapy. RTX in combination with cyclophosphamide /doxorubicin /vincristine /prednisone (R-CHOP) remains the standard frontline regimen for diffuse large B-cell lymphoma. However, suboptimal response and /or resistance to rituximab have remained a challenge in the therapy of B-cell non-Hodgkin's lymphoma (NHL).