Publications by authors named "Keman Xie"
Article Synopsis
- Bisphenol A (BPA) is an endocrine disruptor that negatively impacts the nervous system, leading to anxiety-like behavior and cognitive impairments in mice.
- This study investigates whether an enriched environment (EE) can counteract these effects by enhancing cognitive behavior and reducing anxiety in mice exposed to BPA.
- Results showed that EE treatment improves dendritic spine development, restores excitatory synaptic transmission, and alleviates behavioral issues associated with BPA exposure, highlighting the neuroprotective role of EE.
Chronic pain can induce mood disorders and cognitive dysfunctions, such as anxiety, depression, and learning and memory impairment in humans. However, the specific neural network involved in anxiety- and depression-like behaviors and learning and memory impairment caused by chronic pain remains poorly understood. In this study, behavioral test results showed that chronic pain induced anxiety- and depression-like behaviors, and learning and memory impairment in male mice.
View Article and Find Full Text PDFClinical studies have shown that the mediodorsal thalamus (MD) may play an important role in the development of depression. However, the molecular and circuit mechanisms by which the mediodorsal thalamus (MD) participates in the pathological processes of depression remain unclear. Here, we show that in male chronic social defeat stress (CSDS) mice, the calcium signaling activity of glutamatergic neurons in MD is reduced.
View Article and Find Full Text PDFArticle Synopsis
- - Clinical studies link social defeat to mood-related disorders and learning/memory impairment, but the specific brain networks involved are not fully understood.
- - In experiments with mice subjected to chronic social defeat stress, learning and memory issues were observed alongside mood disorders, with particular neurons in the piriform cortex being activated.
- - Targeted techniques showed that while activating these neurons led to learning/memory impairments, inhibiting them could alleviate the learning issues without impacting mood disorders, suggesting a potential therapeutic avenue.