The relaxation effect of endocannabinoid anandamide on isolated rat bladder and vas deferens tissues and possible mechanisms.

Background: The endocannabinoid system plays important roles in various systems, including the genitourinary system; however, its mechanism of action is not fully understood.

Objectives: This study aimed to investigate the direct relaxant effects of anandamide and its possible mechanisms in isolated rat bladder and vas deferens tissues.

Methods: Twenty-one adult male Wistar albino rats were used.

Effects of taurine on vascular tone.

Taurine is widely distributed at high concentrations in mammalian tissues, and it plays an important role in a wide range of biological effects including modulation of cardiovascular functions. This review summarizes the role of taurine in vascular tone and blood pressure modulation based on experimental and human studies. It is well established that supplementation of taurine prevents development of hypertension in several animal models and p.

Propofol Relaxes Isolated Rat Aorta through BK Activation.

Background: Propofol is an intravenous anesthetic that can be used for the induction and maintenance of anesthesia. In the present study, it was aimed to investigate the mechanism of vasodilator action of propofol in the rat aorta (RA).

Methods: The RA rings were suspended in isolated organ baths and tension was recorded isometrically.

Potassium channels in vascular smooth muscle: a pathophysiological and pharmacological perspective.

Potassium (K ) ion channel activity is an important determinant of vascular tone by regulating cell membrane potential (MP). Activation of K channels leads to membrane hyperpolarization and subsequently vasodilatation, while inhibition of the channels causes membrane depolarization and then vasoconstriction. So far five distinct types of K channels have been identified in vascular smooth muscle cells (VSMCs): Ca -activated K channels (BK ), voltage-dependent K channels (K ), ATP-sensitive K channels (K ), inward rectifier K channels (K ), and tandem two-pore K channels (K P).

Dental resin curing blue light induces vasoconstriction through release of hydrogen peroxide.

Dental resin curing blue light (BL) is frequently used during treatments in dental clinics. However, little is known about the influence of BL irradiation on pulpal blood vessels. The aim of the present study was to investigate the mechanism of effect of BL irradiation on vascular tone.

Taurine relaxes human radial artery through potassium channel opening action.

The vascular actions and mechanisms of taurine were investigated in the isolated human radial artery (RA). RA rings were suspended in isolated organ baths and tension was recorded isometrically. First, a precontraction was achieved by adding potassium chloride (KCl, 45 mM) or serotonin (5-hydroxytryptamine, 5-HT, 30 µM) to organ baths.

The histopathological and pharmacodynamic effects of intradetrusor decorin injected in a rabbit partial bladder outlet obstruction model.

Purpose: To evaluate whether or not the bladder function can be protected by supporting the detrusor with decorin levels during the fibrotic process.

Methods: Forty-two male rabbits were divided into three main groups, partial bladder outlet obstruction (pBOO) group, pBOO + intradetrusor decorin-injected (IDI) group and control group. Both pBOO and pBOO + IDI groups were divided into three subgroups according to the killing schedule.