Developmental age and biological sex influence muscarinic receptor function and neuron morphology within layer VI of the medial prefrontal cortex.

Acetylcholine (ACh) neurotransmission within the medial prefrontal cortex (mPFC) plays an important modulatory role to support mPFC-dependent cognitive functions. This role is mediated by ACh activation of its nicotinic (nAChR) and muscarinic (mAChR) classes of receptors, which are both present on mPFC layer VI pyramidal neurons. While the expression and function of nAChRs have been characterized thoroughly for rodent mPFC layer VI neurons during postnatal development, mAChRs have not been characterized in detail.

Does demonstrator relevance affect social preferences and the social transmission of food preferences in female mice (Mus musculus)?

This study examined whether a history of beneficial social learning experiences affects social partner preferences in laboratory mice (Mus musculus) and whether observer mice acquire adaptive model-based social learning strategies through associative learning. We tested whether observers would come to socially prefer demonstrators who provide beneficial information through the social transmission of food preference (STFP), over demonstrators who do not; and whether they would preferentially attend to and learn from such demonstrators. Observers were given repeated exposures to two demonstrators who differed in whether or not they consistently provided beneficial information (which increased observers' ingestion of food via the STFP).

Rapid effects of estrogens on short-term memory: Possible mechanisms.

Contribution to Special Issue on Fast effects of steroids. Estrogens affect learning and memory through rapid and delayed mechanisms. Here we review studies on rapid effects on short-term memory.

Cage-induced stereotypic behaviour in laboratory mice covaries with nucleus accumbens FosB/ΔFosB expression.

Stereotypic behaviour (SB) occurs in certain human disorders (e.g. autism), and animals treated with stimulants or raised in impoverished conditions, including laboratory mice in standard cages.

Estrogen involvement in social behavior in rodents: Rapid and long-term actions.

This article is part of a Special Issue ("Estradiol and cognition"). Estrogens have repeatedly been shown to influence a wide array of social behaviors, which in rodents are predominantly olfactory-mediated. Estrogens are involved in social behavior at multiple levels of processing, from the detection and integration of socially relevant olfactory information to more complex social behaviors, including social preferences, aggression and dominance, and learning and memory for social stimuli (e.

Activation of the G protein-coupled estrogen receptor, but not estrogen receptor α or β, rapidly enhances social learning.

Social learning is a highly adaptive process by which an animal acquires information from a conspecific. While estrogens are known to modulate learning and memory, much of this research focuses on individual learning. Estrogens have been shown to enhance social learning on a long-term time scale, likely via genomic mechanisms.