Publications by authors named "Kelsie Dougherty"
Background: Equine herpes virus type 1 (EHV-1) infection in horses is associated with upper respiratory disease, neurological disease, abortions, and neonatal death.
Review Question: Does pharmacological therapy decrease either the incidence or severity of disease or infection caused by EHV-1 in domesticated horses?
Methods: A systematic review was preformed searching AGRICOLA, CAB Abstracts, Cochrane, PubMed, Web of Science, and WHO Global Health Index Medicus Regional Databases to identify articles published before February 15, 2021. Selection criteria were original research reports published in peer reviewed journals, and studies investigating in vivo use of therapeutic agents for prevention or treatment of EHV-1 in horses.
Article Synopsis
- Colon cancer stem cells (CSCs) may initiate tumors and lead to cancer relapse, and their behavior is influenced by neighboring enteric glial cells (EGCs) within the tumor microenvironment.
- The research used various cancer models to show that EGCs, when activated by tumor-derived signals, promote the growth and tumorigenicity of CSCs through a specific signaling pathway involving PGE2 and EGFR.
- The study suggests that targeting the interaction between tumor-activated EGCs and CSCs could be a potential strategy for cancer treatment.