Publications by authors named "Kelsey Wells"
Many powerful methods have been employed to elucidate the global transcriptomic, proteomic, or metabolic responses to pathogen-infected host cells. However, the host glycome responses to bacterial infection remain largely unexplored, and hence, our understanding of the molecular mechanisms by which bacterial pathogens manipulate the host glycome to favor infection remains incomplete. Here, we address this gap by performing a systematic analysis of the host glycome during infection by the bacterial pathogen Brucella spp.
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- Scientists studied how horse lung cells (EBECs) react to a fake version of the virus that causes COVID-19 compared to human lung cells (HBECs).
- They found that the horse cells had less of a protein called ACE2, which helps the virus enter cells, making them less likely to get infected.
- This suggests that horses probably won’t get COVID-19 easily, but it's still important to keep an eye on them if they're near people who are sick.
Article Synopsis
- The immune system uses a process called phagocytosis to destroy germs, but some germs, like the one that causes brucellosis, can trick this defense.
- This germ activates a special process that breaks down a protein (BLOS1) needed for moving germs to lysosomes, where they get destroyed.
- When certain cells or mice couldn't use this breakdown process, they were better at fighting off the infection, showing that this protein plays an important role in protecting against germs.