Vitamin K versus warfarin interruption alone in patients without bleeding and an international normalized ratio > 10.

Background: Reversal of an international normalized ratio (INR) > 10 with vitamin K is recommended in patients experiencing bleeding; however, information on outcomes with reversal using vitamin K in non-bleeding patients is lacking.

Objective: To compare clinical and safety outcomes between non-bleeding patients receiving warfarin with an INR > 10 who did and did not receive a prescription for vitamin K.

Patients/methods: This was a retrospective cohort study conducted in an integrated health-care delivery system.