Publications by authors named "Kelsey Holbert"
Article Synopsis
- Obstructive sleep apnea (OSA) is common in asthma patients, and the duration of asthma may increase the risk of developing OSA, indicating a possible link between the two conditions.
- Researchers studied the breathing responses to low oxygen levels in rats with asthma (sensitized with ovalbumin) and compared them to control rats (saline), finding that those with asthma had heightened responses due to increased breathing frequency.
- The study concluded that asthma-related inflammation, rather than mechanical issues in the lungs, may enhance breathing control mechanisms, potentially contributing to the ventilatory instability that could lead to sleep apnea in humans.
Pulmonary hypertension in sickle cell disease is an independent predictor of mortality, yet the pathogenesis of pulmonary vascular disease in chronic hemolytic disorders remains incompletely understood and treatment options are limited primarily to supportive care. The release of extracellular hemoglobin has been implicated in the development of pulmonary hypertension, and in this study we explored the direct effects of hemin, the oxidized moiety of heme, on the pulmonary artery endothelium. We found that low dose hemin exposure leads to significantly increased endothelial cell proliferation, migration, and cytokine release as markers of endothelial dysfunction.
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