Publications by authors named "Kelsey G Stark"
Article Synopsis
- Scientists studied how certain bacteria affect stomach inflammation in mice, which can be similar to humans.
- They found that the bacteria caused only a little inflammation but made the stomach produce more helpful substances against infections.
- When the mice had a food allergy, their stomachs showed a strong immune response, but the bacteria didn’t make this response worse.
There is heterogeneity inherent in the immune responses of individual mice in murine models of food allergy, including anaphylaxis, similar to the clinical heterogeneity observed in humans with food allergies to a defined food. One major driver of this heterogeneity may be differences in the microbiome between sensitized individuals. Our laboratory and others have reported that disruption of the microbiome (dysbiosis) by broad spectrum antibiotics and/or yeast colonization can alter systemic immunity and favor the development of mucosal Type 2 immunity to aeroallergens.
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