Personalized genetic risk counseling to motivate diabetes prevention: a randomized trial.

Objective: To examine whether diabetes genetic risk testing and counseling can improve diabetes prevention behaviors.

Research Design And Methods: We conducted a randomized trial of diabetes genetic risk counseling among overweight patients at increased phenotypic risk for type 2 diabetes. Participants were randomly allocated to genetic testing versus no testing.

Genetic counseling as a tool for type 2 diabetes prevention: a genetic counseling framework for common polygenetic disorders.

Advances in genetic epidemiology have increased understanding of common, polygenic preventable diseases such as type 2 diabetes. As genetic risk testing based on this knowledge moves into clinical practice, we propose that genetic counselors will need to expand their roles and adapt traditional counseling techniques for this new patient set. In this paper, we present a genetic counseling intervention developed for a clinical trial [Genetic Counseling/Lifestyle Change for Diabetes Prevention, ClinicalTrials.

Impact of literacy and numeracy on motivation for behavior change after diabetes genetic risk testing.

Background: Type 2 diabetes genetic risk testing might motivate at-risk patients to adopt diabetes prevention behaviors. However, the influence of literacy and numeracy on patient response to diabetes genetic risk is unknown.

Objective: The authors investigated the association of health literacy, genetic literacy, and health numeracy with patient responses to diabetes genetic risk.

Design of a randomized trial of diabetes genetic risk testing to motivate behavior change: the Genetic Counseling/lifestyle Change (GC/LC) Study for Diabetes Prevention.

Background: The efficacy of diabetes genetic risk testing to motivate behavior change for diabetes prevention is currently unknown.

Purpose: This paper presents key issues in the design and implementation of one of the first randomized trials (The Genetic Counseling/Lifestyle Change (GC/LC) Study for Diabetes Prevention) to test whether knowledge of diabetes genetic risk can motivate patients to adopt healthier behaviors.

Methods: Because individuals may react differently to receiving 'higher' vs 'lower' genetic risk results, we designed a 3-arm parallel group study to separately test the hypotheses that: (1) patients receiving 'higher' diabetes genetic risk results will increase healthy behaviors compared to untested controls, and (2) patients receiving 'lower' diabetes genetic risk results will decrease healthy behaviors compared to untested controls.

Perceived impact of diabetes genetic risk testing among patients at high phenotypic risk for type 2 diabetes.

Objective: Rapid advances in diabetes genetic epidemiology may lead to a new era of "personalized medicine" based on individual genetic risk assessment. There is minimal experience to guide how best to clinically implement such testing so that results (e.g.