Publications by authors named "Kelsey E McNeely"
Photosensitivity is observed in numerous autoimmune diseases and drives poor quality of life and disease flares. Elevated epidermal type I interferon (IFN) production primes for photosensitivity and enhanced inflammation, but the substrates that sustain and amplify this cycle remain undefined. Here, we show that IFN-induced Z-DNA binding protein 1 (ZBP1) stabilizes ultraviolet (UV)B-induced cytosolic Z-DNA derived from oxidized mitochondrial DNA.
View Article and Find Full Text PDFImportance: Patients with mesothelioma often have next-generation sequencing (NGS) of their tumor performed; tumor-only NGS may incidentally identify germline pathogenic or likely pathogenic (P/LP) variants despite not being designed for this purpose. It is unknown how frequently patients with mesothelioma have germline P/LP variants incidentally detected via tumor-only NGS.
Objective: To determine the prevalence of incidental germline P/LP variants detected via tumor-only NGS of mesothelioma.
Article Synopsis
- * A study analyzed a large international group of patients with specific genetic variants (RUNX1, GATA2, DDX41) to identify unique genetic patterns linked to the development of these malignancies, particularly noting different tendencies for early-onset clonal hematopoiesis (CH).
- * Findings suggest that further monitoring and clinical trials should focus on specific genetic variants to improve preemptive treatments and surveillance for patients, especially those with RUNX1 and DDX41 mutations.