The DosR regulon of and adaptation to hypoxia.

Like other tuberculous and nontuberculous mycobacterial pathogens of human lung such as and , is likely exposed to a variety of stressors during infection, including hypoxic conditions inside activated macrophages and in the avascular necrotic regions of granulomas. How survives hypoxic stress to establish a chronic infection is currently not well understood. Using RNA-sequencing, we here show that grown under progressive microaerophilic conditions activates more than 4-fold a subset of 16 genes, the expression of 13 of which is dependent on the two-component system regulator DosRS.