Publications by authors named "Kelsey E Hirotsu"
Background: As the use of melanoma antigen recognized by T cells (MART-1) immunohistochemistry (IHC) with Mohs surgery increases for the treatment of melanoma in situ and invasive melanoma, surgeons should be aware of MART-1 staining patterns of incidental lesions often encountered on frozen sections. Lack of this knowledge can lead to unnecessary additional surgery, increased health care costs, and loss of valuable laboratory staff time and resources.
Objective: To characterize the histopathologic features of incidental lesions encountered during Mohs surgery for melanoma.
Article Synopsis
- Patients with Muir-Torre Syndrome (MTS), a variant of Lynch syndrome, show less aggressive behavior in sebaceous carcinoma (SC) compared to those without MTS.
- The study analyzed data from 2000 to 2019, finding that MTS patients were typically younger, had more tumors located outside of the head/neck region, and exhibited fewer high-grade tumors.
- While MTS status appeared to predict worse overall survival, it did not significantly affect SC-specific survival, indicating that SC's aggressiveness is not increased in MTS patients.
Importance: Mogamulizumab is a monoclonal antibody against CCR4 approved for treatment for mycosis fungoides (MF) and Sézary syndrome (SS). Mogamulizumab-associated rash (MAR) is difficult to differentiate from cutaneous MF or SS, which can lead to unnecessary discontinuation of drug use because of concern for severe drug reaction or incorrect presumption of disease relapse or progression in the skin.
Objective: To examine the most common clinical presentations of MAR in patients with MF or SS and the diagnostic and management challenges.
Rash is one of the most common adverse events observed with mogamulizumab, an anti-C-C chemokine receptor 4 monoclonal antibody approved for previously treated mycosis fungoides (MF) and Sezary syndrome (SS). Given the nonspecific clinical presentations of this rash, histopathologic distinction from MF/SS is critical for informing clinical management. We performed a comprehensive characterization of the histopathologic findings in mogamulizumab-associated rash (MAR) with the integration of high-throughput sequencing of T-cell receptor (TCR) genes.
View Article and Find Full Text PDFBackground: Student-athletes (SAs) have an increased skin cancer risk on account of significant ultraviolet exposure; however, their sun-protective practices are suboptimal. A novel program, Stanford University Network for Sun Protection, Outreach, Research, and Teamwork (SUNSPORT), was designed to target SAs, coaches, and athletic trainers (ATs).
Objective: To measure the impact of educational intervention on sun protection beliefs and practices of SAs.