Chemical proteomics unveils that seventy flavors pearl pill ameliorates ischemic stroke by regulating oxidative phosphorylation.

Ischemic stroke has high mortality and morbidity rates and is the second leading cause of death in the world, but there is no definitive medicine. Seventy Flavors Pearl Pill (SFPP) is a classic formula in Tibetan Medicine. Clinical practice has shown the attenuation effect of SFPP on blood pressure disorders, strokes and their sequelae and other neurological symptoms, but its mechanism remains to be elucidated.

Oxytrodiflavanone A and Oxytrochalcoflavanones A,B: New Biflavonoids from .

Three previously undescribed biflavonoids, oxytrodiflavanone A (), and oxytrochalcoflavanones A,B (,), were isolated from the aerial part of , together with their putative biosynthetic monomers, i.e., (2)-5,7-dihydroxyflavanone (), (2)-7-hydroxyflavanone (), and 2',4'-dihydroxychalcone ().

Azukisapogenol Triterpene Glycosides from Royle.

Eight azukisapogenol triterpene glycosides, including five new compounds, oxychiliotriterpenosides A⁻E (⁻), two new methyl glucuronide derivatives that proved to be artifacts, oxychiliotriterpenoside E-glucuronic acid methyl ester () and myrioside B-glucuronic acid methyl ester (), and a known one, myrioside B (), was isolated from the aerial part of Royle. Their structures were elucidated based on extensive spectroscopic analyses and chemical methods. Triterpene glycosides were first obtained from , and those containing a galactose unit (, , and ) and diglucosidic or triglucosidic linkage at C-29 (⁻), were reported from species for the first time, which might be recognized as a chemotaxonomic feature of .

Structurally Diverse Cytotoxic Dimeric Chalcones from Oxytropis chiliophylla.

Ten isomeric cyclobutane- and cyclohexene-containing chalcone dimers, oxyfadichalcones A-G, were isolated from the aerial parts of Oxytropis chiliophylla. These included six new compounds and three pairs of enantiomers that are being reported from natural sources for the first time. The relative configurations were elucidated by spectroscopic data analysis, while the absolute configurations were determined by comparing the experimental and calculated electronic circular dichroism spectra.

[Subacute toxicity and chemical analysis of Tibetan medicine Oxytropis falcata].

Four different extracts of Oxytropis falcata, including the aerial aqueous extract, and the underground aqueous extract, the aerial lipophilic extract, and the underground lipophilic extract were prepared and then administrated orally to mice at the maximum dose (50 g x kg(-1) x d(-1) calculated by raw material) for fifteen days respectively. Compared with the control group, which was administrated of 1.0% tween-80, the treatment groups did not show significant differences in appearance and behavior.