Publications by authors named "Kelly T McInnes"
Article Synopsis
- The study investigates the roles of glutathione (GSH) and glutaredoxin1 (GRX1) in regulating the activity of copper-transporting P-type ATPases (Cu-ATPases), which are key for maintaining copper levels in cells.
- It shows that fluctuations in copper levels influence how Cu-ATPases interact with GRX1 and undergo glutathionylation, a process that impacts their ability to bind and transport copper.
- Additionally, experiments reveal that reducing GSH or knocking down GRX1 leads to altered intracellular copper levels and highlights their important roles in the redox regulation of Cu-ATPases.
In Alzheimer's disease there is abnormal brain copper distribution, with accumulation of copper in amyloid plaques and a deficiency of copper in neighbouring cells. Excess copper inhibits Abeta (amyloid beta-peptide) production, but the effects of deficiency have not yet been determined. We therefore studied the effects of modulating intracellular copper levels on the processing of APP (amyloid precursor protein) and the production of Abeta.
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