Publications by authors named "Kelly Siu"
Heterotopic ossification (HO) is one of the described phenomena after maxillofacial reconstructive surgery using fibular free flap (FFF) at the reception-site. The aim of this study was to determine the radiological incidence and form of HO along the fibular vascular pedicle as well as the rate of clinical symptoms if present. CT-scans of 102 patients who underwent jaw reconstructive surgery by using FFF from January 2005 to December 2019 were evaluated concerning the presence of HO.
View Article and Find Full Text PDFArticle Synopsis
- - Mutations in the aquaporin AQP2 lead to resistance against the drugs pentamidine and melarsoprol, with specific amino acid changes influencing drug permeation.
- - The study reveals that TbAQP2 has evolved to allow the passage of pentamidine through its central pore, unlike its counterpart TbAQP3, which requires specific modifications to become permeable.
- - Understanding the structural features that enable pentamidine to pass through TbAQP2 might help improve antitrypanosomal treatments and prevent drug resistance, potentially benefiting the broader aquaporin gene family in pharmacology.