Publications by authors named "Kelly S Schoenfelt"
Article Synopsis
- Increased cancer aggressiveness and mortality have been linked to obstructive sleep apnea (OSA), primarily due to intermittent hypoxia (IH), which boosts melanoma growth and metastasis in mice.
- A study revealed that mice exposed to IH for 28 days had 84% larger lung tumors compared to those in normal air, with tumor-associated macrophages (TAMs) shifting from an anti-tumor (M1) to a pro-tumor (M2) phenotype.
- The research indicates that IH alters TAMs, which then enhance cancer cell proliferation, migration, and invasiveness, reinforcing the connection between OSA-related factors and negative cancer outcomes.