Publications by authors named "Kelly Pastor"
Article Synopsis
- Almost all humans carry Candida albicans, which can turn pathogenic in immunocompromised individuals, leading to severe infections.
- Researchers identified two important transcription factors, Zcf15 and Zcf29, that are crucial for the virulence of C. albicans, showing that knockout mutants of these factors are more sensitive to oxidative stress.
- The study highlights how these factors help the fungus adapt to its host environment by regulating nutrient balance and detoxifying reactive oxygen species, offering insights into the evolution and behavior of Candida infections.
Candida albicans is a major fungal pathogen of humans, causing mucosal infections that are difficult to eliminate and systemic infections that are often lethal primarily due to defects in the host's innate status. Here we demonstrate the utility of Caenorhabditis elegans, a model host to study innate immunity, by exploring the role of reactive oxygen species (ROS) as a critical innate response against C. albicans infections.
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