The expression of neuregulin and erbB receptors in human skeletal muscle: effects of progressive resistance training.

The neuregulin/erbB-signaling axis contributes to the development and growth of multiple mammalian tissues including skeletal muscle. In this study, we sought to characterize the native expression of this system in human skeletal muscle and test the hypothesis that a program of progressive resistance training (PRT) would regulate the expression of neuregulin (NRG) and its cognate receptors. Twelve healthy-male subjects underwent 8-weeks of lower-extremity PRT and muscle biopsies were performed at baseline and following 1- and 8-weeks of the intervention.

Weighted stair climbing in mobility-limited older people: a pilot study.

Objectives: To evaluate weighted stair climbing exercise (SCE) as a means of increasing lower extremity muscle power in mobility-limited older people.

Design: Single-blinded, randomized controlled pilot study.

Setting: Human physiology laboratory of a metropolitan university.

High-velocity resistance training increases skeletal muscle peak power in older women.

Objectives: Peak power declines more precipitously than strength with advancing age and is a reliable measure of impairment and a strong predictor of functional performance. We tested the hypothesis that a high-velocity resistance-training program (HI) would increase muscle power more than a traditional low-velocity resistance-training program (LO).

Design: Randomized controlled trial.

The relationship between leg power and physical performance in mobility-limited older people.

Objectives: The purpose of this study was to assess the influence of leg power and leg strength on the physical performance of community-dwelling mobility-limited older people.

Design: Cross-sectional analysis of baseline data from a 12-week randomized controlled exercise-intervention study.

Setting: Exercise laboratory within the Department of Health Science of an urban university.