Spatial and Temporal Resolution of Cyanobacterial Bloom Chemistry Reveals an Open-Ocean as a Talented Producer of Specialized Metabolites.

While the ecological role that sp. play in nitrogen fixation has been widely studied, little information is available on potential specialized metabolites that are associated with blooms and standing stock colonies. While a collection of biological material from a bloom event from North Padre Island, Texas, in 2014 indicated that this species was a prolific producer of chlorinated specialized metabolites, additional spatial and temporal resolution was needed.

Systematic Review of Naloxone Dosing and Adverse Events in the Emergency Department.

Background: Experts recommend using the lowest effective dose of naloxone to balance the reversal of opioid-induced respiratory depression and avoid precipitated opioid withdrawal, however, there is no established dosing standards within the emergency department (ED).

Objectives: The aim of this review was to determine current naloxone dosing practice in the ED and their association with adverse events.

Methods: We conducted a systematic review by searching PubMed, Cochrane, Embase, and EBSCO from 2000-2021.

Isolation of Isotrichophycin C and Trichophycins G-I from a Collection of .

The trichophycin family of compounds are chlorinated polyketides first discovered from environmental collections of a bloom-forming sp. cyanobacterium. In an effort to fully capture the chemical space of this group of metabolites, the utilization of MS/MS-based molecular networking of a extract revealed a metabolome replete with halogenated compounds.