Publications by authors named "Kelly M Wilmas"
Article Synopsis
- The study explores the use of dehydrated complete human placental membrane (dCHPM) allografts as a repair option for Mohs surgical defects on the nose, highlighting that traditional methods may not always be the best choice.
- Twenty patients who underwent this procedure were assessed for aesthetic and functional outcomes using photography and evaluations by blinded observers.
- Results showed a favorable scar assessment with a mean score of 8.4 for observers and 12.6 for patients, indicating that dCHPM allografts are a viable alternative, though the study was limited by a small sample size and being conducted at a single institution.
Article Synopsis
- Basal cell carcinoma (BCC) is the most common type of skin cancer, arising from the basal layer of the epidermis, and its treatment depends on various factors like tumor characteristics and patient attributes.
- Surgical treatments like standard excision and Mohs micrographic surgery (MMS) are primary options that confirm tumor removal, while other therapies may be considered for specific conditions or patient concerns.
- The range of treatment methods for BCC includes not just surgery, but also radiation, immunotherapy, laser treatments, and targeted therapies, showcasing advances in how this cancer can be managed.
Article Synopsis
- cSCC (cutaneous squamous cell carcinoma) is becoming more common due to increased lifespans and better survival rates for associated risk factors, with mortality rates surpassing melanoma in the U.S. and nearing those of melanoma globally.!* -
- The review discusses advancements in cSCC management, including better risk assessment, new treatment options, and improved prevention strategies, particularly through immune checkpoint inhibitors (ICIs) targeting PD-1 and PD-L1.!* -
- ICIs have shown promising results in treating advanced cSCC, offering patients reduced toxicity compared to traditional chemotherapy, longer-lasting responses after treatment, and improved survival rates; ongoing research continues to explore new clinical trials that may shape future management of c
Mycosis fungoides (MF), the most common cutaneous T-cell lymphoma, classically has an indolent clinical course, with lesions slowly progressing from patch to plaque to tumor stage. In some cases, the late stages of disease involve extra-cutaneous dissemination to lymph nodes or viscera. Although this "Alibert-Bazin" type is the prototypic MF, there are several variants and subtypes of MF that may have different clinical implications for treatment and prognosis.
View Article and Find Full Text PDFLocally advanced or metastatic cutaneous squamous cell carcinoma no longer amenable to surgical resection or primary radiation therapy requires an alternative approach to treatment. Until 2018, management consisted of limited systemic chemotherapies, which carried marginal clinical benefit. The introduction of immunotherapy with anti-PD-1 antibodies resulted in alternative treatment options for advanced cutaneous squamous cell carcinoma with substantial antitumor activity, durable response and acceptable safety profile.
View Article and Find Full Text PDFRadiation therapy may be performed for a variety of cutaneous malignancies, depending on patient health status, tumor clinical and histologic features, patient preference, and resource availability. Dermatologists should be able to recognize the clinical scenarios in which radiation therapy is appropriate, as this may reduce morbidity, decrease risk of disease recurrence, and improve quality of life. The second article in this 2-part continuing medical education series focuses on the most common indications for radiation therapy in the treatment of basal cell carcinoma, cutaneous squamous cell carcinoma, dermatofibrosarcoma protuberans, Merkel cell carcinoma, Kaposi sarcoma, angiosarcoma, cutaneous lymphoma, melanoma, undifferentiated pleomorphic sarcoma, and sebaceous carcinoma.
View Article and Find Full Text PDFRadiation therapy offers distinct advantages over other currently available treatments for cutaneous malignancies in certain circumstances. Dermatologists and dermatologic surgeons should be familiar with the available radiation therapy techniques as well as their value and potential limitations in a variety of clinical scenarios. The first article in this 2-part continuing medical education series highlights the mechanisms, modalities, and applications of the most commonly used radiotherapy treatments as they relate to cutaneous oncology.
View Article and Find Full Text PDFArticle Synopsis
- - Sodium tetradecyl sulfate (STS) is FDA-approved for treating varicose veins, but it is also used off-label for various conditions such as telangiectasias and hemangiomas.
- - A review of studies from 1938 to 2016 found STS to be effective for these conditions, though common side effects include pain, swelling, and more serious risks like anaphylaxis and stroke.
- - Despite some limitations in data due to small studies, STS is often chosen for its simplicity and low cost, making it a popular option even when it may not be the most effective treatment available.