Publications by authors named "Kelly L Budge"
Article Synopsis
- In a mouse model of membranous nephropathy (MN) caused by cationic bovine serum albumin (cBSA), the complement regulator decay-accelerating factor (DAF) is increased to control complement activation.
- Research shows that the activation of complement primarily occurs through C3a/C3aR signaling, making these pathways potential targets for new treatments for MN.
- Experiments revealed that without DAF, there was more complement activation and disease severity increased, but blocking C3aR in DAF mice reduced MN severity, highlighting the significant role of complement in the disease's progression.
Article Synopsis
- The study explores the impact of COVID-19 on patients with glomerulonephritis (GN) by analyzing data from 125 GN patients and 83 non-GN controls, focusing on kidney health outcomes over an average follow-up period of 6.4 months.
- Findings indicate that there were no significant differences in mortality or acute kidney injury (AKI) between GN patients and controls, with pre-COVID-19 kidney function (eGFR) being a critical predictor of AKI risk.
- GN patients show a lower likelihood of recovering kidney function post-AKI compared to controls, particularly those with shorter GN diagnoses or higher protein levels, suggesting a need for careful monitoring of these patients after COVID-19.
Article Synopsis
- Acute kidney injury (AKI) is increasingly recognized for its serious risks, such as higher mortality and hospitalization rates, stemming from causes like dehydration and harmful medications.
- Inflammation is a common feature of AKI, contributing to kidney damage and possibly resulting from it, with studies showing the kidneys can regenerate if the damage isn’t too severe.
- Understanding the transition from AKI to chronic kidney disease (CKD) involves studying maladaptive repair mechanisms, and identifying early biomarkers could help personalize treatment for those at risk of developing CKD.
Article Synopsis
- The study investigated the impact of COVID-19 on patients with immune-mediated glomerulonephritis, who are typically on immunosuppressive treatments, by creating the International Registry of COVID infection in glomerulonephritis (IRoc-GN) and examining 40 affected individuals alongside 80 matched controls.
- Findings revealed that patients with glomerulonephritis experienced significantly higher mortality rates (15%) and acute kidney injury (39%) compared to controls (5% and 14%, respectively), although the need for kidney replacement therapy was similar between the two groups.
- Key risk factors linked to worse outcomes in glomerulonephritis patients included lower serum albumin levels and shorter disease duration at the time
Article Synopsis
- Juvenile-onset lupus nephritis (LN) impacts a significant portion of patients with juvenile-onset systemic lupus erythematosus (JSLE) and this study aims to explore the role of human renal glomerular endothelial cells (GEnCs) in this condition.
- Researchers treated conditionally immortalized GEnCs with pro-inflammatory cytokines and analyzed their response through various methods, including quantifying protein secretion and gene expression changes in response to serum from JSLE patients.
- Findings revealed that specific pro-inflammatory stimuli significantly increased the production of various inflammatory proteins and activated key signaling pathways, suggesting that human GEnCs are crucial in the inflammation process associated with LN.
