Evaluation of F-RO-948 PET for Quantitative Assessment of Tau Accumulation in the Human Brain.

The availability of tau PET radioligands enables quantitative assessment of tau density and distribution in the human brain. We evaluated the kinetics of a novel radioligand, F-RO-948 (previously referred to as F-RO6958948), and its ability to identify tau positivity in individual patients with mild Alzheimer disease (AD). Eleven subjects with amyloid-positive mild AD, 5 amyloid-negative older control subjects (OC), and 5 younger control subjects (YC) completed 1 or 2 (4 AD and 5 OC) PET scans with F-RO-948 for 90, 120, or 200 min.