Publications by authors named "Kelly Hurst"
Background: Optimizing resuscitation to reduce inflammation and organ dysfunction following human trauma-associated hemorrhagic shock is a major clinical hurdle. This is limited by the short duration of pre-clinical studies and the sparsity of early data in the clinical setting.
Methods: We sought to bridge this gap by linking preclinical data in a porcine model with clinical data from patients from the Prospective, Observational, Multicenter, Major Trauma Transfusion (PROMMTT) study via a three-compartment ordinary differential equation model of inflammation and coagulation.
Background: Participants who received ketamine at the NIMH were among the first to receive ketamine for depression in controlled clinical trials, providing a unique opportunity to assess long-term outcomes. This analysis evaluated the relationship between participating in a ketamine clinical trial and subsequent ketamine/esketamine use after leaving the research setting.
Methods: Participants seen within the NIMH Experimental Therapeutics and Pathophysiology Branch from 2002 to 2022 (n = 1000) were contacted for follow-up assessment.
This study assessed the relationship between contact with COVID-19 patients and the mental health of healthcare workers (HCWs) in the United States (US). In a convenience sample of 957 HCWs who completed an anonymous online survey between April-May 2020, HCWs who provided direct care to confirmed or suspected COVID-19 patients reported increased depressive and posttraumatic symptoms compared to HCWs with no COVID-19 patient contact. Additionally, more frequent contact was associated with higher distress.
View Article and Find Full Text PDFBackground: Studies of the association between children's depressive symptoms and obesity treatment response show mixed results. Different measurement may contribute to the inconsistent findings, as children's depressive symptoms are often based on parent-report about their child rather than child self-report.
Objectives: We assessed both child- and parent-report of child depressive symptoms as predictors of children's obesity treatment response.
Article Synopsis
- - The study examined eating disorder (ED) pathology in children with overweight or obesity starting family-based behavioral treatment (FBT), revealing distinct patterns of ED pathology and its impact on weight loss.
- - Four unique patterns of ED pathology were identified: low ED pathology, shape/weight concerns (SWC), loss of control (LOC), and high ED pathology, with notable decreases in SWC during treatment.
- - While all children showed a decrease in body mass index (zBMI), those with high ED pathology did not achieve significant weight loss, indicating a need for improved treatment strategies for this group.