Publications by authors named "Kelly E J M Pelzer"
Article Synopsis
- Cardiac troponin T (cTnT) is crucial for diagnosing heart attacks (MI) but is often elevated in patients with end-stage renal disease (ESRD), which complicates interpretation of results.
- The study assessed how different blood collection methods (serum, lithium-heparin plasma, and EDTA plasma) affect cTnT composition and concentration in both MI and ESRD patients.
- Findings showed that while cTnT concentration remains consistent across blood types, the degradation pattern of cTnT varies significantly, with MI patients showing larger proteoforms and ESRD patients displaying small fragments, which is important for developing accurate diagnostic assays.
Thiopurine derivatives, such as azathioprine and mercaptopurine, are standard conventional treatment options in inflammatory bowel disease (IBD). Unfortunately, approximately half of patients discontinue thiopurine therapy within 2 years. To improve the prediction of clinical effectiveness, thiopurine therapy is currently optimized using therapeutic drug monitoring.
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