Publications by authors named "Kelly Drago"
J Biol Chem
September 2024
Article Synopsis
- TREM2 is an important receptor in the immune system that plays roles in inflammation, cell survival, and neuroprotection, with variations linked to Alzheimer's disease.
- The study investigates how TREM2 interacts with heparan sulfate (HS) on microglial cells, revealing that TREM2 forms complexes with HS and requires specific structural features of HS for effective binding.
- Findings suggest that this interaction is crucial for TREM2's role in microglial function, particularly in facilitating the uptake of ApoE3, potentially offering targets for interventions in Alzheimer's disease.
