Publications by authors named "Kelly Daryll Blanz"
Introduction: Nephronophthisis (NPH) is an inherited form of cystic kidney disease with various extrarenal manifestations accounting for the largest amount of endstage renal disease in childhood. Patient mutations of Anks6 have also been found to cause NPH like phenotypes in animal models. However, little is known about functionality of Anks6.
View Article and Find Full Text PDFArticle Synopsis
- Myeloid-derived suppressor cells (MDSC) are immune cells that suppress T-cell activity, particularly in cancer and chronic inflammation, but how T cells affect MDSC is less understood.
- The study investigated how different T-cell types influence the creation and survival of human MDSC, finding that unstimulated CD4 T cells can generate PMN-MDSC from myeloid cells through direct contact and TNF-α signaling.
- Additionally, stimulated CD3 T cells can prolong the life of PMN-MDSC by a mechanism not reliant on TNF-α, instead connecting to IL-2, indicating T cells play key roles in managing MDSC homeostasis.
Macrophages in the arterial intima sustain chronic inflammation during atherogenesis. Under hypercholesterolemic conditions murine Ly6C(high) monocytes surge in the blood and spleen, infiltrate nascent atherosclerotic plaques, and differentiate into macrophages that proliferate locally as disease progresses. Spleen tyrosine kinase (SYK) may participate in downstream signaling of various receptors that mediate these processes.
View Article and Find Full Text PDF