Publications by authors named "Kelly Daescu"
Article Synopsis
- Transcriptional dysregulation is a key feature of prostate cancer, involving altered chromatin interactions between various genomic elements.
- The research identified how structural proteins and master transcription factors, such as the androgen receptor, enhance or alter the regulation of important PCa genes.
- The findings suggest that changes in genome organization significantly contribute to abnormal transcription regulation, particularly in the context of specific genetic risk factors and gene fusions in PCa.
Background: Breast (BCa) and prostate (PCa) cancers are hormone receptor (HR)-driven cancers. Thus, BCa and PCa patients are given therapies that reduce hormone levels or directly block HR activity; but most patients eventually develop treatment resistance. We have previously reported that interleukin-1 (IL-1) inflammatory cytokine downregulates ERα and AR mRNA in HR-positive (HR) BCa and PCa cell lines, yet the cells can remain viable.
View Article and Find Full Text PDFAmyloid β perturbs elevated heme flux induced with neuronal development.
Alzheimers Dement (N Y)
January 2019
Introduction: Heme is a central molecule in mitochondrial respiration and ATP generation in neuronal cells. Thus, we assessed the importance of altered heme metabolism in Alzheimer's disease (AD) pathogenesis.
Methods: To investigate the role of altered heme metabolism in AD, we identified heme-related proteins whose expression is altered in AD patients and mouse models exhibiting amyloid pathology.