Control of urine marking by use of long-term treatment with fluoxetine or clomipramine in cats.

Objectives: To determine whether clomipramine differs from fluoxetine in reducing feline urine marking; whether reduction of marking continues in cats treated >8 weeks; whether recurrence of marking, after abrupt drug withdrawal, is less in cats treated >8 weeks; and whether cats that are successfully treated but resume marking after drug withdrawal can be successfully treated again with the same drug regimen.

Design: Positive-controlled, double-masked clinical trial.

Animals: 22 neutered cats (2 females, 20 males) > or =1 year old with objectionable urine marking.