Oxygen supplementation increases the total work and muscle damage markers but reduces the inflammatory response in COPD patients.

Introduction: Oxygen supplementation (O-Suppl) is recommended for pulmonary rehabilitation with higher exercise intensities. However, high-intensity exercise tends toward muscle damage and a greater inflammatory response. We aimed to investigate the effect of O-Suppl during exercise test (EET) on CRP level and muscle damage (CPK, LDH, lactate) in non-hypoxemic COPD patients.