Alterations in the tissue microenvironment collaborate with cell autonomous genetic changes to contribute to neoplastic progression. The importance of the microenvironment in neoplastic progression is underscored by studies showing that fibroblasts isolated from a tumor stimulate the growth of preneoplastic and neoplastic cells in xenograft models. Similarly, senescent fibroblasts promote preneoplastic cell growth in vitro and in vivo.
View Article and Find Full Text PDFStudies of temporal and spatial changes in phytoplankton biomass and turbidity provide essential information on coral reef ecosystem function and health. Fluctuation of phytoplankton biomass responds to several factors including nutrient inputs, both anthropogenic and natural, while turbidity is mostly affected by sediment resuspension or transport from terrestrial systems. These parameters can be used as sentinels of significant environmental factors "modifying" coral reef systems.
View Article and Find Full Text PDFIrgarol 1051 is a s-triazine herbicide used in popular slime-resistant antifouling paints. It has been shown to be acutely toxic to corals, mangroves and sea grasses, inhibiting photosynthesis at low concentrations (>50 ng l(-1)). We present the first data describing the occurrence of Irgarol 1051 in coastal waters of the Northeastern Caribbean (Puerto Rico (PR) and the US Virgin Islands (USVI)).
View Article and Find Full Text PDFInternational regulation of organotin compounds for use in antifouling paints has led to the development and increased use of replacement compounds, notably the s-triazine herbicide Irgarol 1051. Little is known about the distribution of Irgarol 1051 in tropical waters. Nor has the potential impact of this triazine upon photosynthesis of endosymbiotic microalgae (zooxanthellae) in corals been assessed.
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