Publications by Kelly A McGlinchey

Publications by authors named "Kelly A McGlinchey"

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Targeting CD73 in the tumor microenvironment with MEDI9447.

Carl M Hay Erin Sult Qihui Huang Kathy Mulgrew Stacy R Fuhrmann Kelly A McGlinchey

Oncoimmunology

August 2016

MEDI9447 is a human monoclonal antibody that is specific for the ectoenzyme CD73 and currently undergoing Phase I clinical trials. Here we show that MEDI9447 is a potent inhibitor of CD73 ectonucleotidase activity, with wide ranging immune regulatory consequences. MEDI9447 results in relief from adenosine monophosphate (AMP)-mediated lymphocyte suppression in vitro and inhibition of mouse syngeneic tumor growth in vivo.

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