Soy isoflavones avert chronic inflammation-induced bone loss and vascular disease.

Background: Evidence from epidemiological, clinical and animal studies suggests a link may exist between low bone density and cardiovascular disease, with inflammatory mediators implicated in the pathophysiology of both conditions. This project examined whether supplementation with soy isoflavones (IF), shown to have anti-inflammatory properties, could prevent tissue expression of TNF-alpha and the development of skeletal pathology in an animal model of chronic inflammation.

Methods: Eight-week old, intact, female C57BL/6J mice were used.