Publications by authors named "Kelly A Considine"
Article Synopsis
- Acetaminophen poisoning is primarily treated using N-acetylcysteine (NAC), with a traditional three-bag protocol, but a simpler two-bag protocol has been gaining popularity as an alternative.
- A review of 12 articles showed that the two-bag protocol is as effective as the three-bag regimen in preventing liver injury, with no significant differences in liver damage rates.
- The two-bag regimen was associated with fewer non-allergic anaphylactoid reactions compared to the three-bag regimen, indicating it may be a safer option for patients.
Methods: We reviewed the electronic medical record of critically ill adults who received a continuous infusion of ketamine for ≥24 hours during invasive mechanical ventilation in three hospitals over a two-year period. We captured data including ketamine indication, dose, unintended effects, and adjustments to coadministered sedatives or opioids. We analyzed these data to determine the incidence of reported unintended effects of ketamine infusion (primary outcome) and changes in exposure to coadministered sedatives or opioids during ketamine use (secondary outcome).
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- High dose insulin (HDI) is an important treatment for calcium channel blocker (CCB) poisoning, particularly effective for verapamil toxicity but now increasingly relevant for amlodipine poisonings due to rising cases.
- A study comparing amlodipine and non-dihydropyridine (non-DHP) poisoned patients revealed that those poisoned by amlodipine required more vasopressors and higher doses of epinephrine, indicating a potentially greater severity of vasodilatory effects.
- The results suggest that amlodipine poisoning leads to more pronounced vasodilation compared to other CCBs, as evidenced by the increased use of rescue methylene blue in amlodipine cases.