Calcineurin is a key enzyme in skeletal muscle that supports slow fiber types and muscle repair, making it significant for improving endurance and muscle function.
Neurogranin (Ng), typically found in the brain, also exists in skeletal muscle, where it regulates calcineurin activity by binding to calmodulin (CaM).
Reducing Ng levels in muscle cells enhances calcineurin signaling, leading to increased expression of proteins related to muscle growth and fusion, indicating Ng's novel role as a regulator in this process.