Publications by authors named "Kelley Lobean McKinley"
Article Synopsis
- Newborns given antibiotics to treat infections may have problems with the good bacteria in their tummies, which can affect their health later on.
- A study looked at how these antibiotics influence the germs in preterm babies and found many types of antibiotic resistance genes, even in babies who hadn’t received antibiotics directly.
- Babies who weren't treated had healthier and more varied bacteria in their guts compared to those who were treated with antibiotics.
Enterocyte-specific deletion of metal transporter Zip14 (Slc39a14) alters intestinal homeostasis through epigenetic mechanisms.
Am J Physiol Gastrointest Liver Physiol
March 2023
Zinc has anti-inflammatory properties using mechanisms that are unclear. Zip14 (Slc39a14) is a zinc transporter induced by proinflammatory stimuli and is highly expressed at the basolateral membrane of intestinal epithelial cells (IECs). Enterocyte-specific ablation () in mice was developed to study the functions of this transporter in enterocytes.
View Article and Find Full Text PDFAntibiotic use in neonates can have detrimental effects on the developing gut microbiome, increasing the risk of morbidity. A majority of preterm neonates receive antibiotics after birth without clear evidence to guide this practice. Here microbiome, metabolomic, and immune marker results from the routine early antibiotic use in symptomatic preterm Neonates (REASON) study are presented.
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