Assessing 5-Year Outcomes of an Academic Pediatrics-Community Partnership Focused on Rural Child Health.

Background: The Resident Education in Advocacy and Child Health (REACH) pathway at a large academic pediatric residency program in the Northwest includes an academic-community partnership in a rural community. Few academic-community partnership evaluations have focused on community values. REACH trainees conducted a 5-year evaluation of the partnership using community-generated outcomes measures.

Impact of sociodemographic factors and previous interactions with the health care system on institutional trust in three racial/ethnic groups.

Objective: Our objective was to explore whether there are differences in institutional trust across racial/ethnic groups and what factors might contribute to these differences.

Methods: We studied a convenience sample of 569 adults in Chicago grocery stores who self-identified as African American, Mexican-Hispanic, or white. We measured institutional trust and dichotomized responses into "high" and "low" trust.

Regulation of estrogen receptor α N-terminus conformation and function by peptidyl prolyl isomerase Pin1.

Estrogen receptor alpha (ERα), a key driver of growth in the majority of breast cancers, contains an unstructured transactivation domain (AF1) in its N terminus that is a convergence point for growth factor and hormonal activation. This domain is controlled by phosphorylation, but how phosphorylation impacts AF1 structure and function is unclear. We found that serine 118 (S118) phosphorylation of the ERα AF1 region in response to estrogen (agonist), tamoxifen (antagonist), and growth factors results in recruitment of the peptidyl prolyl cis/trans isomerase Pin1.